Evidence map›Paper›PMID 34434971›Full record

ArticleFrontiers in cardiovascular medicine2021

The Brain-Heart Link: A Case Report of a Critically Located Multiple Sclerosis Lesion in the Brainstem Leading to Recurrent Takotsubo Syndrome.

Florentijn Risseeuw, Pegah Masrori, Ingrid Baar, Simon Nicolay, Constantijn Franssen, Barbara Willekens

Abstract readCase Reports
In one paragraph

Article in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. The role of central autonomic nervous system dysfunction in Takotsubo syndrome: a systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022
    Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Florentijn RisseeuwDepartment of Cardiology, Antwerp University Hospital, Edegem, Belgium.
Pegah MasroriDepartment of Neurology, Antwerp University Hospital, Edegem, Belgium.
Ingrid BaarDepartment of Neurology, Antwerp University Hospital, Edegem, Belgium.
Simon NicolayDepartment of Radiology, Antwerp University Hospital, Edegem, Belgium.
Constantijn FranssenDepartment of Cardiology, Antwerp University Hospital, Edegem, Belgium.
Barbara WillekensDepartment of Neurology, Antwerp University Hospital, Edegem, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various central nervous system (CNS) diseases, including neurovascular and neuroinflammatory diseases, can lead to stress cardiomyopathy, also known as Takotsubo syndrome (TTS). We present a case of a 69-year-old woman with cardiovascular comorbidities, suffering from repeated episodes of TTS and respiratory failure due to a critical lesion in the brainstem, leading to a diagnosis of multiple sclerosis (MS). Despite aggressive treatment, intractable and recurrent symptoms in our patient occurred. Repeated bouts of autonomic dysfunction and respiratory failure ultimately led to installment of palliative care and the patient passing away. TTS should raise suspicion for underlying neurological diseases. Thorough questioning of previous neurological symptoms and extensive neurological workup is warranted. MS should be considered as a trigger of TTS also in elderly patients with cardiovascular risk factors.

Indexed as

autonomic dysfunctionbrainstemcase reportmultiple sclerosisstress cardiomyopathyTakotsubo syndrome

Identifiers

PMID34434971
PMCPMC8381246

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.