Evidence map›Paper›PMID 34434755›Full record

ArticleMethodsX2021

Control of internal validity threats in a modified adaptive platform design using Halili Physical Therapy Statistical Analysis Tool (HPTSAT).

Adi Halili

Abstract read
In one paragraph

Article in MethodsX, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Adi HaliliHalili Physical Therapy, 268 E River Rd. #130, Tucson, AZ 85704, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some of the challenges in evaluating the effectiveness of physical therapy practice stem from the common lack of interventional standardization, as well as problems with both the availability and routine use of specific, valid outcome tools. But even if these issues are dealt with, there are still significant validity threats when trying to understand the effectiveness of physical therapy interventions. Among the most critical internal validity threats: repeated testing effect, study sample uniformity, and increase in type I or type II error. The purpose of this analysis is to illustrate how these internal validity threats were controlled using the Halili Physical Therapy Statistical Analysis Tool (HPTSAT). The original concept behind the HPTSAT tool was the adaptive platform design used in the PREVAIL I and II protocols(1,2,3). However, this concept has been significantly expanded upon in the HPTSAT design to allow for the simultaneous analysis of hundreds of treatment combinations while controlling for the above-mentioned critical internal validity threats.•HPTSAT allows for concurrent computerized analysis modeled and improved upon the adaptive platform design used in the PREVAIL I and II protocols.•This analysis is possible because the tool isolates the average rate of change (ARC5) instead of average change after treatment.•This paper provides the mathematical basis for the algorithm used in the tool to control for several internal validity threats including repeated testing effect, study sample uniformity, and increase in type I and II error.

Indexed as

Adaptive platform modelHPTSATInternal validityPhysical therapyPREVAIL IIStatistical analysisSystemic manual therapy

Identifiers

PMID34434755
PMCPMC8374171

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.