Evidence map›Paper›PMID 34434551›Full record

ReviewTherapeutic advances in infectious disease

Fungal infections in hematopoietic stem-cell transplant patients: a review of epidemiology, diagnosis, and management.

Mandeep Singh Rahi, Vishal Jindal, Prachi Pednekar, Jay Parekh, Kulothungan Gunasekaran, Sorabh Sharma, Michael Stender, Ishmael A Jaiyesimi

Open access · goldAbstract readReview
In one paragraph

Review in Therapeutic advances in infectious disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Emerging Applications of Triazole Antifungal Drugs.International journal of molecular sciences · 2026
    Review
  7. Review
  8. Fungal Infections in Pediatric Patients With Hematologic Malignancies and Stem Cell Transplantation: Impact on the Upper and Lower Respiratory Systems.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. A Lateral-Flow Device for the Rapid Detection ofDiagnostics (Basel, Switzerland) · 2024
    Article
  15. Article
  16. Annals of medicine and surgery (2012) · 2023
    Article
  17. Article
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mandeep Singh RahiDivision of Pulmonary Diseases and Critical Care Medicine, Yale-New Haven Health Bridgeport Hospital, 267 Grant Street, Bridgeport, CT 06610, USA.ORCID https://orcid.org/0000-0002-4445-5758
Vishal JindalDivision of Hematology and Oncology, Oakland University-William Beaumont School of Medicine, Royal Oak, MI, USA.
Prachi PednekarDepartment of Internal Medicine, Yale-New Haven Health Bridgeport Hospital, Bridgeport, CT, USA.
Jay ParekhDepartment of Internal Medicine, Yale-New Haven Health Bridgeport Hospital, Bridgeport, CT, USA.
Kulothungan GunasekaranDivision of Pulmonary Diseases and Critical Care Medicine, Yale-New Haven Health Bridgeport Hospital, Bridgeport, CT, USA.
Sorabh SharmaDepartment of Internal Medicine, Banner University Medical Center, Tucson, AZ, USA.
Michael StenderDivision of Hematology and Oncology, Oakland University-William Beaumont School of Medicine, Royal Oak, MI, USA.
Ishmael A JaiyesimiDivision of Hematology and Oncology, Oakland University-William Beaumont School of Medicine, Royal Oak, MI, USA.
Bridgeport Hospital · USOakland University · USBanner - University Medical Center Tucson · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

The advent of bone marrow transplant has opened doors to a different approach and offered a new treatment modality for various hematopoietic stem-cell-related disorders. Since the first bone marrow transplant in 1957, there has been significant progress in managing patients who undergo bone marrow transplants. Plasma-cell disorders, lymphoproliferative disorders, and myelodysplastic syndrome are the most common indications for hematopoietic stem-cell transplant. Despite the advances, invasive fungal infections remain a significant cause of morbidity and mortality in this high-risk population. The overall incidence of invasive fungal infection in patients with hematopoietic stem-cell transplant is around 4%, but the mortality in patients with allogeneic stem-cell transplant is as high as 13% in one study. Type of stem-cell transplant, conditioning regimen, and development of graft-

Indexed as

anti-fungalbone marrow transplantfungal infectionsfungal prophylaxisstem cell transplant

Identifiers

PMID34434551
PMCPMC8381463
OpenAlexW3193757485

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.