Evidence map›Paper›PMID 34434543›Full record

ReviewPulmonary circulation

Recent advancements in pulmonary arterial hypertension and right heart failure research: overview of selected abstracts from ATS2020 and emerging COVID-19 research.

Francois Potus, Andrea L Frump, Soban Umar, Rebecca R Vanderpool, Imad Al Ghouleh, Yen-Chun Lai

Abstract readReview
In one paragraph

Review in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Francois PotusPulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et Pneumologie de Quebec City, Quebec, Canada.
Andrea L FrumpDivision of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Soban UmarDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0001-8036-3079
Rebecca R VanderpoolDivision of Translational and Regenerative Medicine, University of Arizona, Tucson, AZ, USA.
Imad Al GhoulehPittsburgh Heart, Lung and Blood Vascular Medicine Institute, and Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Yen-Chun LaiDivision of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID https://orcid.org/0000-0002-4703-5708

Funding

Role of Skeletal Muscle in Pulmonary Vascular RemodelingR01HL142638 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Yen Chun Charly Lai · 2018 to 2026
$4.9M
Endothelial Reprogramming in Pulmonary HypertensionR01HL148712 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AL GHOULEH, IMAD · 2019 to 2023
$1.9M
Investigating the molecular mechanisms of right ventricular failure in pulmonary hypertensionR01HL161038 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Soban Umar · 2022 to 2026
$1.9M
Role of the Novel MicroRNA-125b in Pulmonary Hypertension Associated with Pulmonary FibrosisK08HL141995 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI UMAR, SOBAN · 2019 to 2023
$879k
NHLBI NIH HHS K08 HL141995NHLBI NIH HHS R01 HL142638NHLBI NIH HHS R01 HL148712NHLBI NIH HHS R01 HL161038
6 · The paper itself

Abstract

Each year the American Thoracic Society (ATS) Conference brings together scientists who conduct basic, translational and clinical research to present on the recent advances in the field of respirology. Due to the Coronavirus Disease of 2019 (COVID-19) pandemic, the ATS2020 Conference was held online in a series of virtual meetings. In this review, we focus on the breakthroughs in pulmonary hypertension research. We have selected 11 of the best basic science abstracts which were presented at the ATS2020 Assembly on Pulmonary Circulation mini-symposium "What's New in Pulmonary Arterial Hypertension (PAH) and Right Ventricular (RV) Signaling: Lessons from the Best Abstracts," reflecting the current state of the art and associated challenges in PH. Particular emphasis is placed on understanding the mechanisms underlying RV failure, the regulation of inflammation, and the novel therapeutic targets that emerged from preclinical research. The pathologic interactions between pulmonary hypertension, right ventricular function and COVID-19 are also discussed.

Indexed as

ATSbasic science researchCOVID-19pulmonary hypertensionTranslational research

Identifiers

PMID34434543
PMCPMC8381443

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.