Evidence map›Paper›PMID 34434304›Full record

ArticleJournal of medical cases2019

Regional Anesthesia Facilitates the Early Recognition of Local Anesthetic Toxicity.

Emmanuel Alalade, Lance M Relland, Kristin Chenault, Nicole Elsey, Molly Fuchs, Seth Alpert, Joseph Tobias

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical cases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emmanuel AlaladeDepartment of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Lance M RellandDepartment of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Kristin ChenaultDepartment of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Nicole ElseyDepartment of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Molly FuchsDepartment of Pediatric Urology, Nationwide Children's Hospital, Columbus, OH, USA.
Seth AlpertDepartment of Pediatric Urology, Nationwide Children's Hospital, Columbus, OH, USA.
Joseph TobiasDepartment of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, Columbus, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rising concerns regarding the potential long-term neurocognitive effects of general anesthetic agents have renewed an interest in using regional anesthesia instead of general anesthesia in infants. Although generally safe and effective, the primary risk associated with regional anesthesia relates to the use of large doses of local anesthetic agents and the potential for local anesthetic systemic toxicity (LAST). We present three infants who suffered LAST after receiving regional anesthesia instead of general anesthesia. The early signs and symptoms were quickly identified in the awake state thereby allowing for cessation of continuous drug administration and a rapid response to treat LAST before progression to severe sequelae.

Indexed as

Local anesthesia systemic toxicityRegional anesthesiaSpinal anesthesia

Identifiers

PMID34434304
PMCPMC8383700

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.