Evidence map›Paper›PMID 34434227›Full record

ArticleNeural plasticity2021

Muscle Fiber Diameter and Density Alterations after Stroke Examined by Single-Fiber EMG.

Chengjun Huang, Bo Yao, Xiaoyan Li, Sheng Li, Ping Zhou

Open access · goldAbstract read
In one paragraph

Article in Neural plasticity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Chengjun HuangGuangdong Work Injury Rehabilitation Center, Guangzhou, China.
Bo YaoInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Xiaoyan LiDepartment of Bioengineering, University of Maryland, College Park, MA, USA.
Sheng LiDepartment of Physical Medicine and Rehabilitation, University of Texas Health Science Center at Houston, Houston, TX, USA.
Ping ZhouUniversity of Health and Rehabilitation Sciences, Qingdao, China.ORCID 0000-0002-4394-2677
Chinese Academy of Medical Sciences & Peking Union Medical College · CNGuangdong Work Injury Rehabilitation Hospital · CNMedical College of Wisconsin · USThe University of Texas Health Science Center at Houston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study presents single-fiber electromyography (EMG) analysis for assessment of paretic muscle changes after stroke. Single-fiber action potentials (SFAPs) were recorded from the first dorsal interosseous (FDI) muscle bilaterally in 12 individuals with hemiparetic stroke. The SFAP parameters, including the negative peak duration and the peak-peak amplitude, were measured and further used to estimate muscle fiber diameter through a model based on the quadratic function. The SFAP parameters, fiber density, and muscle fiber diameter derived from the model were compared between the paretic and contralateral muscles. The results show that SFAPs recorded from the paretic muscle had significantly smaller negative peak duration than that from the contralateral muscle. As a result, the derived muscle fiber diameter of the paretic muscle was significantly smaller than that of the contralateral muscle. The fiber density of the paretic muscle was significantly higher than that of the contralateral muscle. These results provide further evidence of remodeled motor units after stroke and suggest that paretic muscle weakness can be due to both complex central and peripheral neuromuscular alterations.

Indexed as

Action PotentialsAgedElectromyographyFemaleHumansMaleMiddle AgedMuscle Fibers, SkeletalMuscle, SkeletalParesisStroke

Identifiers

PMID34434227
PMCPMC8380495
OpenAlexW3193388139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.