Evidence map›Paper›PMID 34434158›Full record

ArticleFrontiers in neurology2021

Excessive Daytime Sleepiness in Obstructive Sleep Apnea Patients Treated With Continuous Positive Airway Pressure: Data From the European Sleep Apnea Database.

Maria R Bonsignore, Jean L Pepin, Fabio Cibella, Calogero D Barbera, Oreste Marrone, Johan Verbraecken, Tarja Saaresranta, Ozen K Basoglu, Georgia Trakada, Izolde Bouloukaki and 9 more

Abstract read
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Trial
  2. Occupational sleep restriction: a missing piece in residual EDS of PAP-adherent OSA?Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Overall Mortality and Comorbidities in Obstructive Sleep Apnea in Poland.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  9. Article
  10. Observational
  11. Sleep Medicine-What's in a Name?Journal of sleep research · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Patients with obstructive sleep apnea in Germany.Sleep & breathing = Schlaf & Atmung · 2025
    Article
  16. Article
  17. The role of microsleeps to estimate sleepiness at the wheel and near-miss accidents in obstructive sleep apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  18. Article
  19. Global Prevalence of Excessive Daytime Sleepiness in Patients with Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Maria R BonsignoreSleep Disordered Breathing Clinic, Pulmonary Division, PROMISE Department, University of Palermo, Palermo, Italy.
Jean L PepinHP2 Laboratory, U1042, INSERM, Grenoble Alpes University, Grenoble, France.
Fabio CibellaNational Research Council (CNR), Institute for Biomedical Research and Innovation (IRIB), Palermo, Italy.
Calogero D BarberaSleep Disordered Breathing Clinic, Pulmonary Division, PROMISE Department, University of Palermo, Palermo, Italy.
Oreste MarroneNational Research Council (CNR), Institute for Biomedical Research and Innovation (IRIB), Palermo, Italy.
Johan VerbraeckenMultidisciplinary Sleep Disorders Centre, Antwerp University Hospital and University Hospital Antwerp, Antwerp, Belgium.
Tarja SaaresrantaDivision of Medicine, Department of Pulmonary Diseases, Turku University Hospital, Turku, Finland.
Ozen K BasogluDepartment of Chest Diseases, Ege University Faculty of Medicine, Izmir, Turkey.
Georgia TrakadaDivision of Pulmonology, Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Izolde BouloukakiSleep Disorders Unit, Department of Respiratory Medicine, Medical School, University of Crete, Crete, Greece.
Walter T McNicholasDepartment of Respiratory and Sleep Medicine, School of Medicine, St. Vincent's Hospital Group, University College Dublin, Dublin, Ireland.
Sébastien BaillyHP2 Laboratory, U1042, INSERM, Grenoble Alpes University, Grenoble, France.
Athanasia PatakaRespiratory Failure Unit, G Papanikolaou Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
John A KvammeEar, Nose and Throat-Department, Foerde Central Hospital, Foerde, Norway.
Holger HeinPrivate Practice and Sleep Lab for Internal Medicine, Pulmonary Medicine and Sleep Medicine, Geesthacht, Germany.
Stefan MihaicutaVictor Babes University of Medicine and Pharmacy, CardioPrevent Foundation, Timisoara, Romania.
Ludger GroteSleep Disorders Centre, Respiratory Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
Francesco FanfullaRespiratory Function and Sleep Medicine Unit, Scientific Institutes of Pavia and Montescano, Istituti Clinici Scientifici Maugeri, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Pavia, Italy.
ESADA Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive daytime sleepiness (EDS) is a symptom of obstructive sleep apnea (OSA) that resolves under treatment with continuous positive airway pressure (CPAP). In some patients, sleepiness persists despite CPAP treatment. We retrospectively analyzed data on subjective residual EDS, assessed as an Epworth Sleepiness Scale score (ESS) >10, in patients from the European Sleep Apnea Database (

Indexed as

CPAP adherenceEpworth Sleepiness Scalefollow-upresidual sleepinesssleep durationsleep latency

Identifiers

PMID34434158
PMCPMC8381644

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.