Evidence map›Paper›PMID 34434001›Full record

ArticleJournal of orthopaedics

Reamer-irrigator-aspirate versus bone marrow aspirate concentrate for osteoprogenitor cell retention and osteoinductive protein release on cancellous bone.

Jane Liu, Brett D Crist, Aaron M Stoker, James P Stannard, James L Cook

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jane LiuUniversity of Missouri Department of Orthopaedic Surgery, 1100 Virginia Ave., Columbia, MO, 65212, USA.
Brett D CristUniversity of Missouri Department of Orthopaedic Surgery, 1100 Virginia Ave., Columbia, MO, 65212, USA.
Aaron M StokerUniversity of Missouri Department of Orthopaedic Surgery, 1100 Virginia Ave., Columbia, MO, 65212, USA.
James P StannardUniversity of Missouri Department of Orthopaedic Surgery, 1100 Virginia Ave., Columbia, MO, 65212, USA.
James L CookUniversity of Missouri Department of Orthopaedic Surgery, 1100 Virginia Ave., Columbia, MO, 65212, USA.
University of Missouri · USCenter for Neuroscience and Regenerative Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone defects often require operative intervention with the use of bone graft. Two sources of autologous bone graft include reamer-irrigator-aspirate (RIA) and bone marrow aspirate concentrate (BMC). Osteoprogenitor cells and osteoconductive proteins have been identified in both sources. This study collected samples of these cells and proteins from a canine model and cultured them on human cancellous allograft bone blocks. Findings suggest that BMC may be preferred for indications that allow for delivery via injection, saturation of the patient's tissues, or an implanted scaffold, whereas RIA may be preferred when the biologic augment is delivered as a scaffold or graft.

Indexed as

Autologous bone graftBone healingBone marrow aspirate concentratePre-clinical animal modelReamer-irrigator-aspirate

Identifiers

PMID34434001
PMCPMC8371145
OpenAlexW3190188895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.