ArticleNature2021
APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 63 citations in OpenAlex.
- TNFSF13 insufficiency disrupts human colonic epithelial cell growth and associated B cell dynamics.The Journal of clinical investigation · 2026Article
- TNFSF13 Drives Atherosclerosis Progression by Targeting Macrophage Senescence.International journal of medical sciences · 2026Article
- The Dual Role of Extracellular Vesicles in Aging and Age-Related Diseases: Pathophysiology and Therapeutic Potential.International journal of nanomedicine · 2026Review
- Taking its TOLL: the role of toll-like receptor 4 in human health and disease, and its potential as a therapeutic target.Frontiers in immunology · 2026Review
- Apolipoprotein B-containing lipoproteins in atherogenesis.Nature reviews. Cardiology · 2025Review
- Circular RNAs increase during vascular cell differentiation and are biomarkers for vascular disease.Cardiovascular research · 2025Article
- Progress in macrophage immune regulation of atherosclerosis.American journal of translational research · 2025Review
- TNF superfamily molecules in atherosclerosis: mechanistic insights and therapeutic translation.Frontiers in immunology · 2025Review
- Endothelial Dysfunction and Cardiovascular Disease: Hyperbaric Oxygen Therapy as an Emerging Therapeutic Modality?Journal of cardiovascular development and disease · 2024Review
- Atheroimmunology: keeping the immune system in atherosclerosis in check.Nature reviews. Cardiology · 2024Article
- Cuproptosis and copper deficiency in ischemic vascular injury and repair.Apoptosis : an international journal on programmed cell death · 2024Review
- Unique and redundant roles of mouse BCMA, TACI, BAFF, APRIL, and IL-6 in supporting antibody-producing cells in different tissues.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Therapeutic Avenues to Modulate B-Cell Function in Patients With Cardiovascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Peripheral inflammatory response in people after acute ischaemic stroke and isolated spontaneous cervical artery dissection.Scientific reports · 2024Article
- Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities.Nature metabolism · 2024Review
- B-cells in pulmonary arterial hypertension: friend, foe or bystander?The European respiratory journal · 2024Review
- Review
- Mechanisms modulating foam cell formation in the arterial intima: exploring new therapeutic opportunities in atherosclerosis.Frontiers in cardiovascular medicine · 2024Review
- Immune cell-mediated features of atherosclerosis.Frontiers in cardiovascular medicine · 2024Review
- The circadian clock gene BMAL1 modulates autoimmunity features in lupus.Frontiers in immunology · 2024Article
Corrections and comments
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Authors and funding
34 authors at 11 institutions in 7 countries.
Dimitrios TsiantoulasDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria. dimitris.tsiantoulas@meduniwien.ac.at.ORCID http://orcid.org/0000-0002-7743-3192
Mahya EslamiDepartment of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Georg ObermayerDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Marc ClementDivision of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.
Diede SmeetsDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Florian J MayerDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Máté G KissDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-9215-8328
Lennart EndersCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.ORCID http://orcid.org/0000-0001-8341-3350
Juliane WeißerCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Laura GöderleDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0003-1037-3137
Jordi LambertDivision of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.
Florian FrommletCenter for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
André MuellerCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Tim HendrikxDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Maria Ozsvar-KozmaDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Florentina PorschDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-2633-6632
Laure WillenDepartment of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Taras AfonyushkinDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Jane E MurphyDivision of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-2201-9469
Per FogelstrandInstitute of Medicine, University of Gothenburg, Göteborg, Sweden.
Olivier DonzéAdipogen Life Sciences, Epalinges, Switzerland.
Gerard PasterkampUniversity Medical Center Utrecht, Utrecht, the Netherlands.
Matthias HokeDepartment of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Stefan KubicekCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.ORCID http://orcid.org/0000-0003-0855-8343
Helle F JørgensenDivision of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-7909-2977
Nicolas DanchinAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou, Department of Cardiology, Paris, France.
Tabassome SimonAssistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint Antoine, Department of Clinical Pharmacology and Clinical Research Platform of East of Paris (URCEST-CRB-CRC), Paris, France.
Hubert ScharnaglClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Winfried MärzClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Jan BorénInstitute of Medicine, University of Gothenburg, Göteborg, Sweden.ORCID http://orcid.org/0000-0003-0786-8091
Henry HessTranslational Innovation Platform Immunology, Merck KGaA, Darmstadt, Germany.
Ziad Mallat *Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-0443-7878
Pascal Schneider *Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.ORCID http://orcid.org/0000-0003-0677-9409
Christoph J BinderDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria. christoph.binder@meduniwien.ac.at.ORCID http://orcid.org/0000-0001-8313-7050
Austrian Academy of Sciences · ATMedical University of Vienna · ATUniversity of Cambridge · GBUniversity of Lausanne · CHMedical University of Graz · ATUniversity of Gothenburg · SEInserm · FRMerck (Germany) · DEUniversité Paris Cité · FRUniversité Sorbonne Nouvelle · FRUniversity Medical Center Utrecht · NL
Funding
British Heart Foundation CH/10/001/27642British Heart Foundation FS/15/38/31516European Research Council
Abstract
Atherosclerotic cardiovascular disease causes heart attacks and strokes, which are the leading causes of mortality worldwide
Indexed as
AnimalsAtherosclerosisB-Cell Maturation AntigenBinding SitesCardiovascular DiseasesFemaleHeparan Sulfate ProteoglycansHumansMaleMiceMice, Inbred C57BLProtein BindingTransmembrane Activator and CAML Interactor ProteinTumor Necrosis Factor Ligand Superfamily Member 13B-Cell Maturation AntigenHeparan Sulfate ProteoglycansperlecanTNFSF13 protein, humanTransmembrane Activator and CAML Interactor ProteinTumor Necrosis Factor Ligand Superfamily Member 13
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.