ArticleNature2021
Clonal dynamics in early human embryogenesis inferred from somatic mutation.
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In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
98 citing papers in PubMed, 1 synthesis or guideline pooled it, 137 citations in OpenAlex.
- Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia.Nature medicine · 2022Pooled it
- Computational approaches for multimodal lineage tracing.Nature reviews. Genetics · 2026Review
- Somatic mutations and genome mosaicism in aging and disease.Experimental & molecular medicine · 2026Review
- Clonal evolution and mutational trajectories of metastatic colorectal cancer shaped by anticancer therapies.Nature communications · 2026Article
- DREAM repressive activity links somatic mutation, lifespan and disease.Nature aging · 2026Article
- Somatic mutations distinguish melanocyte subpopulations in human skin.Nature cell biology · 2026Article
- DIAG: A Framework for Evaluating Whole-Genome Amplification Quality in Single-Cell SNV Analysis.Biology · 2026Article
- Mapping the zygote-to-adult developmental cell phylogeny in Arabidopsis thaliana reveals a three-cell rule of branching.Nature plants · 2026Article
- Somatic mutations and clonal evolution in normal tissues and cancer development.Experimental & molecular medicine · 2026Review
- Long-read sequencing of families reveals increased germline and postzygotic mutation rates in repetitive DNA.Nature communications · 2026Article
- Recent Progress in Characterizing Germline Mutations and Their Transmission Across Generations.Advances in experimental medicine and biology · 2026Review
- Reconstructing the lifelong history of cells and tissues via somatic mutation analysis.Cellular and molecular life sciences : CMLS · 2025Review
- Advances in single-cell DNA sequencing enable insights into human somatic mosaicism.Nature reviews. Genetics · 2025Review
- High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer.Science (New York, N.Y.) · 2025Article
- Comprehensive benchmarking of somatic single-nucleotide variant and indel detection at ultra-low allele fractions using short- and long-read data.bioRxiv : the preprint server for biology · 2025Article
- Clonal dynamics of monozygotic twinning in early human embryogenesis.bioRxiv : the preprint server for biology · 2025Article
- Article
- Genome instability in mammalian embryos implications for genome editing, development, and evolution.Current opinion in genetics & development · 2025Review
- APOBEC3A drives deaminase mutagenesis in human gastric epithelium.Genome research · 2025Article
- SNPmanifold: detecting single-cell clonality and lineages from single-nucleotide variants using binomial variational autoencoder.Genome biology · 2025Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 6 institutions in 1 country.
Seongyeol Park *Graduate School of Medical Science and Engineering (GSMSE), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.ORCID http://orcid.org/0000-0002-9236-5853
Nanda Maya Mali *Department of Anatomy, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Ryul Kim *Graduate School of Medical Science and Engineering (GSMSE), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Jeong-Woo ChoiDepartment of Anatomy, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Junehawk LeeKorea Institute of Science and Technology Information (KISTI), Daejeon, Republic of Korea.
Joonoh LimGraduate School of Medical Science and Engineering (GSMSE), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Jung Min ParkDepartment of Anatomy, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Jung Woo ParkKorea Institute of Science and Technology Information (KISTI), Daejeon, Republic of Korea.
Donghyun KimDepartment of Anatomy, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Taewoo KimGraduate School of Medical Science and Engineering (GSMSE), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Kijong YiGraduate School of Medical Science and Engineering (GSMSE), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.ORCID http://orcid.org/0000-0003-1656-1243
June Hyug ChoiDepartment of Anatomy, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Seong Gyu KwonDepartment of Anatomy, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Joo Hee HongDepartment of Anatomy, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Jeonghwan YoukGraduate School of Medical Science and Engineering (GSMSE), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.ORCID http://orcid.org/0000-0002-6761-3958
Yohan AnGraduate School of Medical Science and Engineering (GSMSE), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.ORCID http://orcid.org/0000-0001-7560-769X
Su Yeon KimGraduate School of Medical Science and Engineering (GSMSE), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Soo A OhGraduate School of Medical Science and Engineering (GSMSE), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Youngoh KwonGENOME INSIGHT Inc, Daejeon, Republic of Korea.
Dongwan HongDepartment of Medical Informatics, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-7816-1299
Moonkyu KimDepartment of Immunology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Dong Sun KimDepartment of Anatomy, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Ji Young ParkDepartment of Pathology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.ORCID http://orcid.org/0000-0002-7571-1064
Ji Won OhDepartment of Anatomy, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. ohjiwon@knu.ac.kr.ORCID http://orcid.org/0000-0001-5742-5120
Young Seok JuGraduate School of Medical Science and Engineering (GSMSE), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea. ysju@kaist.ac.kr.ORCID http://orcid.org/0000-0002-5514-4189
Korea Advanced Institute of Science and Technology · KRKyungpook National University · KRKyungpook National University Hospital · KRCatholic University of Korea · KRGenome Research Foundation · KRKorea Institute of Science & Technology Information · KR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular dynamics and fate decision in early human embryogenesis remain largely unknown owing to the challenges of performing studies in human embryos
Indexed as
MutationCell LineageClone CellsDNA, MitochondrialEmbryo, MammalianEmbryonic DevelopmentFemaleHumansMaleMutation RateDNA, Mitochondrial
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.