Evidence map›Paper›PMID 34433964›Full record

ArticleNature2021

Hypothalamic dopamine neurons motivate mating through persistent cAMP signalling.

Stephen X Zhang, Andrew Lutas, Shang Yang, Adriana Diaz, Hugo Fluhr, Georg Nagel, Shiqiang Gao, Mark L Andermann

Open access · greenAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
20.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 127 citations in OpenAlex.

  1. Article
  2. A molecular integrator of sleep duration and interruption.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Targeting prostaglandin ENature communications · 2025
    Article
  18. Article
  19. Review
  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Stephen X ZhangDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Andrew LutasDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Shang YangInstitute of Physiology, Department of Neurophysiology, Biocenter, Julius-Maximilians-University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0001-6671-7571
Adriana DiazDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Hugo FluhrDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Georg NagelInstitute of Physiology, Department of Neurophysiology, Biocenter, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Shiqiang GaoInstitute of Physiology, Department of Neurophysiology, Biocenter, Julius-Maximilians-University of Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0001-6190-9443
Mark L AndermannDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. manderma@bidmc.harvard.edu.ORCID http://orcid.org/0000-0002-9882-933X
Beth Israel Deaconess Medical Center · USUniversity of Würzburg · DE

Funding

Neuromodulatory mechanisms underlying vagus nerve stimulation therapy for Alzheimer's diseaseDP1AT010971 · NCCIH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ANDERMANN, MARK L · 2019 to 2023
$6.6M
Neural Pathway Linking Nutritional State To Food-Cue Responses In Insular CortexR01DK109930 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ANDERMANN, MARK L · 2016 to 2020
$2.2M
Hunger modulation of food cue responses in amygdala by dopamine and ghrelinF32DK112589 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LUTAS, ANDREW · 2017 to 2019
$121k
NCCIH NIH HHS DP1 AT010971NIDDK NIH HHS F32 DK112589NIDDK NIH HHS R01 DK109930NIH HHS DP1 AT010971-02S1
6 · The paper itself

Abstract

Transient neuromodulation can have long-lasting effects on neural circuits and motivational states

Indexed as

Sexual Behavior, AnimalSignal TransductionAnimalsCopulationCyclic AMPCyclic AMP-Dependent Protein KinasesDopamineDopaminergic NeuronsDriveFemaleHypothalamusMaleMiceOptogeneticsPreoptic AreaSatiety ResponseCyclic AMPCyclic AMP-Dependent Protein KinasesDopamine

Identifiers

PMID34433964
PMCPMC8884112
OpenAlexW3193574244

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.