ArticleNature2021
The mutational landscape of human somatic and germline cells.
Abstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 250 papers.
0numbers the graph read from it
0cells of the map it votes in
250citing papers in PubMed
23.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
250 citing papers in PubMed, 366 citations in OpenAlex.
- Comprehensive Genomic Analysis of Normal and Cancer Cells Elucidates the Elevated Mutational Burden in Cancer.Cancer research · 2026Article
- Article
- Motif-centered analyses reveal universal and tissue-specific mutagenic mechanisms operating in the human body.NAR cancer · 2026Article
- High-grade serous ovarian cancer is associated with increased TP53 mutation burden in uterine lavage.NPJ precision oncology · 2026Article
- DNA Damage Recognition by Bacterial and Human Adenine-DNA Glycosylases: Insights from Non-Canonical Substrates.Biomolecules · 2026Article
- Landscape of parental postzygotic mutations across >11,000 rare disease trios.American journal of human genetics · 2026Article
- Article
- Chitosan oligosaccharide lactate (COL) chosen from different derivatives protects DNA against environmental stressors.Analytical and bioanalytical chemistry · 2026Article
- Somatic mutations and genome mosaicism in aging and disease.Experimental & molecular medicine · 2026Review
- Evolving patterns of co-mutations from tumor initiation to metastatic progression.Nature genetics · 2026Article
- Article
- AI-driven neoantigen identification: a comprehensive review from somatic variant calling to T cell recognition.Journal of translational medicine · 2026Review
- The Effect of Age and Sex on the Rate of Germline Mutations in Barn Owls.Genome biology and evolution · 2026Article
- Article
- Clonal evolution and mutational trajectories of metastatic colorectal cancer shaped by anticancer therapies.Nature communications · 2026Article
- Genes shielded, repeats exposed: mutation bias in the midge Chironomus riparius.G3 (Bethesda, Md.) · 2026Article
- DREAM repressive activity links somatic mutation, lifespan and disease.Nature aging · 2026Article
- Charting single-cell lineages with synthetic and natural barcodes.Nature reviews. Genetics · 2026Review
- What sets the mutation rate of a cell type in an animal species?PLoS biology · 2026Article
- A sibling study of variation in parental mutation rates.bioRxiv : the preprint server for biology · 2026Article
190 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
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Authors and funding
28 authors at 8 institutions in 3 countries.
Luiza Moore *Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0001-5315-516X
Alex Cagan *Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-7857-4771
Tim H H Coorens *Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-5826-3554
Matthew D C NevilleCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0001-5816-7936
Rashesh SanghviCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-7703-9216
Mathijs A SandersCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.
Thomas R W OliverCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0003-4306-0102
Daniel LeongamornlertCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-3486-3168
Peter EllisCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.
Ayesha NooraniCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.
Thomas J MitchellCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0003-0761-9503
Timothy M ButlerCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0001-5803-1035
Yvette HooksCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.
Anne Y WarrenDepartment of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Mette JorgensenGreat Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Kevin J DawsonCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.
Andrew MenziesCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.
Laura O'NeillCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.
Calli LatimerCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.
Mabel TengCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.
Ruben van BoxtelPrincess Máxima Center for Pediatric Oncology and Oncode Institute, Utrecht, Netherlands.ORCID http://orcid.org/0000-0003-1285-2836
Christine A Iacobuzio-DonahueDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-4672-3023
Inigo MartincorenaCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0003-1122-4416
Rakesh HeerTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Peter J CampbellCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-3921-0510
Rebecca C FitzgeraldMRC Cancer Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-3434-3568
Michael R StrattonCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK. mrs@sanger.ac.uk.ORCID http://orcid.org/0000-0001-6035-153X
Raheleh RahbariCancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK. rr11@sanger.ac.uk.ORCID http://orcid.org/0000-0002-1839-7785
Wellcome Sanger Institute · GBCambridge University Hospitals NHS Foundation Trust · GBUniversity of Cambridge · GBErasmus MC · NLGreat Ormond Street Hospital for Children NHS Foundation Trust · GBJohns Hopkins University · USNewcastle upon Tyne Hospitals NHS Foundation Trust · GBOncode Institute · NL
Funding
Cancer Research UK 21777Cancer Research UK 27114Cancer Research UK 27176Medical Research CouncilWellcome Trust
Abstract
Over the course of an individual's lifetime, normal human cells accumulate mutations
Indexed as
Germ-Line MutationMutation RateAgedClone CellsFemaleGerm CellsHealthHumansMaleMicrodissectionMiddle AgedOrgan SpecificityOxidative StressSpermatogonia
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.