Evidence map›Paper›PMID 34433905›Full record

ArticleInternational journal of obesity (2005)2021

Contrasting dorsal caudate functional connectivity patterns between frontal and temporal cortex with BMI increase: link to cognitive flexibility.

Jizheng Zhao, Peter Manza, Jun Gu, Huaibo Song, Puning Zhuang, Fulei Shi, Zhengqi Dong, Cheng Lu, Gene-Jack Wang, Dongjian He

Abstract read
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In one paragraph

Article in International journal of obesity (2005), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Jizheng ZhaoCollege of Mechanical and Electronic Engineering, Northwest A&F University, Yangling, Shaanxi, China. zhaojizheng@nwsuaf.edu.cn.ORCID http://orcid.org/0000-0002-7901-5576
Peter ManzaLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA.
Jun GuDepartment of Endocrinology, The First Affiliated Hospital of Hebei Northern University, Zhangjiakou, Hebei, China.
Huaibo SongCollege of Mechanical and Electronic Engineering, Northwest A&F University, Yangling, Shaanxi, China.
Puning ZhuangCollege of Mechanical and Electronic Engineering, Northwest A&F University, Yangling, Shaanxi, China.
Fulei ShiCollege of Mechanical and Electronic Engineering, Northwest A&F University, Yangling, Shaanxi, China.
Zhengqi DongCollege of Mechanical and Electronic Engineering, Northwest A&F University, Yangling, Shaanxi, China.
Cheng LuCollege of Mechanical and Electronic Engineering, Northwest A&F University, Yangling, Shaanxi, China.
Gene-Jack WangLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA. gene-jack.wang@nih.gov.ORCID http://orcid.org/0000-0002-5017-9905
Dongjian HeCollege of Mechanical and Electronic Engineering, Northwest A&F University, Yangling, Shaanxi, China. hdj168@nwsuaf.edu.cn.
Northwest A&F University · CNNational Institute on Alcohol Abuse and Alcoholism · USNorth West Agriculture and Forestry University · CNHebei North University · CN

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

backgroundObesity is associated with brain intrinsic functional reorganization. However, little is known about the BMI-related interhemispheric functional connectivity (IHFC) alterations, and their link with executive function in young healthy adults.

methodsWe examined voxel-mirrored homotopic connectivity (VMHC) patterns in 417 young adults from the Human Connectome Project. Brain regions with significant association between BMI and VMHC were identified using multiple linear regression. Results from these analyses were then used to determine regions for seed-voxel FC analysis, and multiple linear regression was used to explore the brain regions showing significant association between BMI and FC. The correlations between BMI-related executive function measurements and VMHC, as well as seed-voxel FC, were further examined.

resultsBMI was negatively associated with scores of Dimensional Change Card Sort Test (DCST) assessing cognitive flexibility (r = -0.14, p = 0.006) and with VMHC of bilateral inferior parietal lobule, insula and dorsal caudate. The dorsal caudate emerged as a nexus for BMI-related findings: greater BMI was associated with greater FC between caudate and hippocampus and lower FC between caudate and several prefrontal nodes (right inferior frontal gyrus, anterior cingulate cortex, and middle frontal gyrus). The FC between right caudate and left hippocampus was negatively associated with scores of DCST (r = -0.15, p = 0.0018).

conclusionsHigher BMI is associated with poorer cognitive flexibility performance and IHFC in an extensive set of brain regions implicated in cognitive control. Larger BMI was associated with higher caudate-medial temporal lobe FC and lower caudate-dorsolateral prefrontal cortex FC. These findings may have relevance for executive function associated with weight gain among otherwise healthy young adults.

Indexed as

Body Mass IndexAdultCognitionConnectomeDorsolateral Prefrontal CortexFemaleHumansMaleTemporal Lobe

Identifiers

PMID34433905
OpenAlexW3194509356

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.