ArticleeNeuro
Information Theoretic Approaches to Deciphering the Neural Code with Functional Fluorescence Imaging.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Modulation of speed-dependent acetylcholine release in the hippocampus by spatial task engagement.Cell reports · 2025Article
- Distinct brain regions map olfactory and visual spaces.bioRxiv : the preprint server for biology · 2025Article
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- Brain region-specific gain modulation of place cells by VIP neurons.Nature communications · 2025Article
- MINT: A toolbox for the analysis of multivariate neural information coding and transmission.PLoS computational biology · 2025Article
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- Navigating uncertainty: reward location variability induces reorganization of hippocampal spatial representations.bioRxiv : the preprint server for biology · 2025Article
- Medial entorhinal cortex mediates learning of context-dependent interval timing behavior.Nature neuroscience · 2024Article
- Hierarchical Gradients of Encoded Spatial and Sensory Information in the Neocortex Are Attenuated by Dorsal Hippocampal Lesions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Lateral entorhinal cortex subpopulations represent experiential epochs surrounding reward.Nature neuroscience · 2024Article
- Full field-of-view virtual reality goggles for mice.Neuron · 2023Article
- Lateral entorhinal cortex subpopulations represent experiential epochs surrounding reward.bioRxiv : the preprint server for biology · 2023Article
- Article
- Hippocampus Maintains a Coherent Map Under Reward Feature-Landmark Cue Conflict.Frontiers in neural circuits · 2022Article
- Behavior determines the hippocampal spatial mapping of a multisensory environment.Cell reports · 2021Article
- Choice of method of place cell classification determines the population of cells identified.PLoS computational biology · 2021Article
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2 authors.
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Abstract
Information theoretic metrics have proven useful in quantifying the relationship between behaviorally relevant parameters and neuronal activity with relatively few assumptions. However, these metrics are typically applied to action potential (AP) recordings and were not designed for the slow timescales and variable amplitudes typical of functional fluorescence recordings (e.g., calcium imaging). The lack of research guidelines on how to apply and interpret these metrics with fluorescence traces means the neuroscience community has yet to realize the power of information theoretic metrics. Here, we used computational methods to create mock AP traces with known amounts of information. From these, we generated fluorescence traces and examined the ability of different information metrics to recover the known information values. We provide guidelines for how to use information metrics when applying them to functional fluorescence and demonstrate their appropriate application to GCaMP6f population recordings from mouse hippocampal neurons imaged during virtual navigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.