ArticleeNeuro
Divergence in Population Coding for Space between Dorsal and Ventral CA1.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- Pyramidal-cell-specific hemispheric asymmetry shapes dorsoventral CA1 dynamics during rest and exploratory behavior.bioRxiv : the preprint server for biology · 2026Article
- Article
- Review
- Emotional shaping of spatial encoding along the dorsal ventral axis of the hippocampus.Frontiers in systems neuroscience · 2026Review
- Discrete and differentiated encoding of distinct components of spatial experience occurs within the proximodistal subfields of the dorsoventral axis of the hippocampus.Frontiers in behavioral neuroscience · 2026Article
- A Positive Allosteric Modulator of the SERCA Pump Rescues Hippocampal Neuronal Circuits Dysfunction and Cognitive Defects in a Mouse Model of Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Identification of a Hippocampus-to-Zona Incerta Projection involved in Motor Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Differential disruptions in population coding along the dorsal-ventral axis of CA1 in the APP/PS1 mouse model of Aβ pathology.PLoS computational biology · 2024Article
- Adult neurogenesis in the ventral hippocampus decreased among animal models of neurodevelopmental disorders.Frontiers in neural circuits · 2024Article
- Working memory and reward increase the accuracy of animal location encoding in the medial prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice.Journal of neuroinflammation · 2023Article
- From synapses to circuits and back: Bridging levels of understanding in animal models of Alzheimer's disease.The European journal of neuroscience · 2022Review
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Molecular, anatomic, and behavioral studies show that the hippocampus is structurally and functionally heterogeneous, with dorsal hippocampus implicated in mnemonic processes and spatial navigation and ventral hippocampus involved in affective processes. By performing electrophysiological recordings of large neuronal populations in dorsal and ventral CA1 in head-fixed mice navigating a virtual environment, we found that this diversity resulted in different strategies for population coding of space. Populations of neurons in dorsal CA1 showed more complex patterns of activity, which resulted in a higher dimensionality of neural representations that translated to more information being encoded, as compared ensembles in vCA1. Furthermore, a pairwise maximum entropy model was better at predicting the structure of these global patterns of activity in ventral CA1 as compared with dorsal CA1. Taken together, the different coding strategies we uncovered likely emerge from anatomic and physiological differences along the longitudinal axis of hippocampus and that may, in turn, underpin the divergent ethological roles of dorsal and ventral CA1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.