ArticleScience advances2021
Ultrafast, tough, and adhesive hydrogel based on hybrid photocrosslinking for articular cartilage repair in water-filled arthroscopy.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed.
- Multifunctional ultrafast hydrogel for arthroscopic surgery: An enzymatically cross-linked, nanosilicate-reinforced system promotes dual cartilage and subchondral bone regeneration.Journal of orthopaedic translation · 2026Article
- Cellulose and Its Derivatives in Drug Delivery: Recent Advances and Applications.Pharmaceutics · 2026Review
- DLP-bioprinted ultrabiomimetic trachea with spatiotemporal angiogenesis regulation for segmental airway reconstruction.Science advances · 2026Article
- One-pot fabrication of high-strength Janus hydrogel for wet tissue hemostasis and intestinal/intrauterine anti-adhesion.Nature communications · 2026Article
- Biobased adhesive hydrogels for wound management and tissue repair: From materials to advanced applications.APL bioengineering · 2026Review
- GelMA Hydrogel/Alginate-Based Scaffolds: 3D Bioprinting for Cartilage Tissue Engineering.Tissue engineering and regenerative medicine · 2026Article
- Ultrafast crosslinking, strongly adhesiveBioactive materials · 2026Article
- Advances in Cellulose-Based Hydrogels for Drug Delivery: Preparation, Modification and Challenges.Gels (Basel, Switzerland) · 2025Review
- Charge balance transition enabledBioactive materials · 2025Article
- Tough PEGDA-Based Bioadhesive Hydrogels for High-Strength In Situ Cartilage Adhesion.ACS omega · 2025Article
- Bioadhesive and antioxidant hydrogel by MoSMaterials today. Bio · 2025Article
- Immune-modulated adhesive hydrogel for enhancing osteochondral graft adhesion and cartilage repair.Bioactive materials · 2025Article
- Dumbbell-shaped hydrogel plug for annulus fibrosus repair: From material design to in vivo validation.Journal of orthopaedic translation · 2025Article
- Integrated biomimetic bioprinting of perichondrium with cartilage for auricle reconstruction.Bioactive materials · 2025Article
- Unlocking the potential of injectable hydrogels for cartilage repair.Regenerative medicine · 2025Review
- Covalently reactive microparticles imbibe blood to form fortified clots for rapid hemostasis and prevention of rebleeding.Nature communications · 2025Article
- Hyaluronic acid as a versatile building block for the development of biofunctional hydrogels: In vitro models and preclinical innovations.Materials today. Bio · 2025Article
- Quercetin prevents the loss of chondrogenic capacity in expansion cultured human auricular chondrocytes by alleviating mitochondrial dysfunction.Regenerative therapy · 2025Article
- Evolving functional hydrogel strategies for cartilage engineering: from fundamentals to functional regeneration.Burns & trauma · 2025Review
- Photoinitiator-free light-mediated crosslinking of dynamic polymer and pristine protein networks.Biomaterials science · 2024Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A hydrogel scaffold for direct tissue-engineering application in water-irrigated, arthroscopic cartilage repair, is badly needed. However, such hydrogels must cure quickly under water, bind strongly and permanently to the surrounding tissue, and maintain sufficient mechanical strength to withstand the hydraulic pressure of arthroscopic irrigation (~10 kilopascal). To address these challenges, we report a versatile hybrid photocrosslinkable (HPC) hydrogel fabricated though a combination of photoinitiated radical polymerization and photoinduced imine cross-linking. The ultrafast gelation, high mechanical strength, and strong adhesion to native tissue enable the direct use of these hydrogels in irrigated arthroscopic treatments. We demonstrate, through in vivo articular cartilage defect repair in the weight-bearing regions of swine models, that the HPC hydrogel can serve as an arthroscopic autologous chondrocyte implantation scaffold for long-term cartilage regeneration, integration, and reconstruction of articular function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.