ArticleScience advances2021
A distributed circuit for associating environmental context with motor choice in retrosplenial cortex.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Retrosplenial cortex enables context-dependent goal-directed sensorimotor transformation.eLife · 2026Article
- CortexCAM: A Camera Array Microscope for Cortex-Wide Cellular Imaging in Freely Locomoting Mice.Research square · 2026Article
- Anterior and posterior retrosplenial cortex form distinct visuospatial circuits in the mouse.Nature communications · 2026Article
- Cortex-Wide Cellular Imaging in Freely Locomoting Mice Using Cortex Camera Array Microscope (CortexCAM).bioRxiv : the preprint server for biology · 2026Article
- Disrupted cortex-wide dynamics impair motor planning in Shank3-mutant mice.bioRxiv : the preprint server for biology · 2026Article
- Brain region-specific gain modulation of place cells by VIP neurons.Nature communications · 2025Article
- FOS mapping reveals two complementary circuits for spatial navigation in mouse.Scientific reports · 2024Article
- Egocentric neural representation of geometric vertex in the retrosplenial cortex.Nature communications · 2024Article
- Differential stability of task variable representations in retrosplenial cortex.Nature communications · 2024Article
- Connectomic reconstruction predicts the functional organization of visual inputs to the navigation center of thebioRxiv : the preprint server for biology · 2023Article
- The Evolution and Future Development of Attention Networks.Journal of Intelligence · 2023Article
- A distributed and efficient population code of mixed selectivity neurons for flexible navigation decisions.Nature communications · 2023Article
- Coregistration of heading to visual cues in retrosplenial cortex.Nature communications · 2023Article
- Distinct mesoscale cortical dynamics encode search strategies during spatial navigation.bioRxiv : the preprint server for biology · 2023Article
- Review
- Article
- Neural basis of topographical disorientation in the primate posterior cingulate gyrus based on a labeled graph.AIMS neuroscience · 2022Article
- Experience-dependent plasticity modulates ongoing activity in the antennal lobe and enhances odor representations.Cell reports · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
During navigation, animals often use recognition of familiar environmental contexts to guide motor action selection. The retrosplenial cortex (RSC) receives inputs from both visual cortex and subcortical regions required for spatial memory and projects to motor planning regions. However, it is not known whether RSC is important for associating familiar environmental contexts with specific motor actions. We test this possibility by developing a task in which motor trajectories are chosen based on the context. We find that mice exhibit differential predecision activity in RSC and that optogenetic suppression of RSC activity impairs task performance. Individual RSC neurons encode a range of task variables, often multiplexed with distinct temporal profiles. However, the responses are spatiotemporally organized, with task variables represented along a posterior-to-anterior gradient along RSC during the behavioral performance, consistent with histological characterization. These results reveal an anatomically organized retrosplenial cortical circuit for associating environmental contexts with appropriate motor outputs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.