Evidence map›Paper›PMID 34433508›Full record

ArticleJournal of the International Neuropsychological Society : JINS2022

Neuropsychological Profiles of Older Adults with Superior

Amanda Cook Maher, Beth Makowski-Woidan, Alan Kuang, Hui Zhang, Sandra Weintraub, M Marsel Mesulam, Emily Rogalski

Open access · greenAbstract read
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. WDR12 and HIVEP3 are contributors to cognitive preservation in Amish SuperAgers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Parallel patterns of cognitive aging in marmosets and macaques.bioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Correlates of SuperAging in Two Population-Based Samples of Hispanic Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Evaluation of a Computable Phenotype for Successful Cognitive Aging.Mayo Clinic proceedings. Innovations, quality & outcomes · 2023
    Article
  17. NIH ToolboxJournal of the International Neuropsychological Society : JINS · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Amanda Cook MaherDepartment of Psychiatry, Neuropsychology Division, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-6229-4743
Beth Makowski-WoidanMesulam Center for Cognitive Neurology & Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Alan KuangDepartment of Preventative Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Hui ZhangDepartment of Preventative Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Sandra WeintraubMesulam Center for Cognitive Neurology & Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
M Marsel MesulamMesulam Center for Cognitive Neurology & Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Emily RogalskiMesulam Center for Cognitive Neurology & Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Northwestern University · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Neuropathology CoreP30AG013854 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BIGIO, EILEEN H. · 1996 to 2020
$28.9M
Research Education Core FP30AG072977 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR · 2021 to 2026
$26.3M
Vascular and Behavioral Determinants of Superior Memory Performance from Continuous Monitoring of Everyday ActivitiesU19AG073153 · NIA · UNIVERSITY OF CHICAGO · PI GEULA, CHANGIZ, MESULAM, MAREK-MARSEL M · 2021 to 2025
$19.1M
Cognitive SuperAging: A model to explore resilience and resistance to aging and Alzheimers diseaseR01AG067781 · NIA · UNIVERSITY OF CHICAGO · PI GEULA, CHANGIZ, MESULAM, MAREK-MARSEL M · 2020 to 2025
$3.7M
Exceptional Cognitive Aging: Neuropsychologic, Anatomic and Pathologic CorrelatesR01AG045571 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEULA, CHANGIZ, MESULAM, MAREK-MARSEL M · 2014 to 2019
$2.6M
Exceptional Cognitive Aging: Neuropsychologic, Anatomic and Pathologic CorrelatesR56AG045571 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEULA, CHANGIZ, MESULAM, MAREK-MARSEL M · 2019 to 2019
$1.4M
NCATS NIH HHS UL1 TR001422NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG072977NIA NIH HHS R01 AG045571NIA NIH HHS R01 AG067781NIA NIH HHS R56 AG045571NIA NIH HHS U19 AG073153
6 · The paper itself

Abstract

objectiveSuperAgers are adults over the age of 80 with superior episodic memory performance and at least average-for-age performance in non-episodic memory domains. This study further characterized the neuropsychological profile of SuperAgers compared to average-for-age episodic memory peers to determine potential cognitive mechanisms contributing to their superior episodic memory performance.

methodRetrospective analysis of neuropsychological test data from 56 SuperAgers and 23 similar-age peers with average episodic memory was conducted. Independent sample

resultsAs a group, SuperAgers had better scores than their average memory peers on measures of attention, working memory, naming, and speeded set shifting. Scores on tests of processing speed, visuospatial function, verbal fluency, response inhibition, and abstract reasoning did not differ. On an individual level, there was variability among SuperAgers with regard to non-episodic memory performance, with some performing above average-for-age across cognitive domains while others performed in the average-for-age range on non-memory tests. Across all participants, attention and executive function scores explained 20.4% of the variance in episodic memory scores.

conclusionsAs a group, SuperAgers outperformed their average memory peers in multiple cognitive domains, however, there was considerable intragroup variability suggesting that SuperAgers' episodic memory strength is not simply related to globally superior cognitive functioning. Attention and executive function performance explained approximately one-fifth of the variance in episodic memory and maybe areas to target with cognitive interventions.

Indexed as

Memory, EpisodicAgedCognitionExecutive FunctionHumansNeuropsychological TestsRetrospective StudiesAttentionCognitive agingExecutive functionHealthy agingMemoryNeuropsychology

Identifiers

PMID34433508
PMCPMC8881565
OpenAlexW3195590412

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.