ArticleBMC veterinary research2021
Effects of different feeding regimens with protease supplementation on growth, amino acid digestibility, economic efficiency, blood biochemical parameters, and intestinal histology in broiler chickens.
Article in BMC veterinary research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Effects of double-low rapeseed meal on growth performance, meat quality, gut microbiota, and nitrogen excretion in Cherry Valley ducks based on low-protein dietary strategies.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Effects of protease and lipase supplementation in starter diet on growth performance, small intestine morphology, and immunity in young broilers.Veterinary and animal science · 2026Article
- Impact of microencapsulated DL-methionine on intestinal health, immune gene expression, and economic returns in broilers chickens.Poultry science · 2026Article
- Effect of enzymatic cottonseed protein on serum biochemical profiles, slaughter performance, meat quality, and volatile flavor compounds of broilers.BMC veterinary research · 2026Article
- Probiotics and enzymes in weaned piglets' diets can lower belly nosing frequency and improve performance and nitrogen balance.Tropical animal health and production · 2026Article
- Can dietary protease ameliorate performance and gut integrity in broilers fed on a diet low in digestible lysine?Poultry science · 2025Article
- Growth performance of male broiler chickens in different growth phases in response to amino acid concentrations in the pre-starter diet.Journal of animal science and technology · 2025Article
- Effects of Feeding Poultry Slaughterhouse Byproduct Meal on the Growth Performance, Digestibility, Antioxidant Status and Histological Parameters of Broilers.Veterinary medicine and science · 2025Article
- Optimizing the zymogram of exogenous proteases in broiler diets by in vitro simulated gastrointestinal digestion and response surface methodology.Scientific reports · 2025Article
- Protease andAnimals : an open access journal from MDPI · 2025Article
- Comparative Study of Duodenal Histology in Three Lamb Breeds Fed Two Different Rations.Veterinary medicine and science · 2025Article
- Effects of high-level dietary distillers dried grains with solubles supplemented with multienzymes on growth performance, nutrient utilization, intestinal morphology, and pellet quality in broiler chickens.Veterinary world · 2024Article
- Multiprotease improves amino acid release in vitro, energy, and nutrient utilization in broilers fed diets varying in crude protein levels.Poultry science · 2024Article
- Comparison study between single enzyme and multienzyme complex in distiller's dred grains with soluble supplemented diet in broiler chicken.Journal of animal science and technology · 2024Article
- Effects of dietary multienzymes on the growth performance, digestive enzyme activity, nutrient digestibility, excreta noxious gas emission, and nutrient transporter gene expression in white feather broilers.Journal of animal science · 2024Article
- New Insights into the Effects of Microbial Muramidase Addition in the Diets of Broiler Chickens.Animals : an open access journal from MDPI · 2023Article
- Impacts of Dietary Lysine and Crude Protein on Performance, Hepatic and Renal Functions, Biochemical Parameters, and Histomorphology of Small Intestine, Liver, and Kidney in Broiler Chickens.Veterinary sciences · 2023Article
- Effects of reduced-protein diets with protease supplementation on growth, carcass yield, intestinal morphology, organ development, nutrient digestibility, and blood biochemical of broiler chickens.Translational animal science · 2023Article
- Protease or Clostridium butyricum addition to a low-protein diet improves broiler growth performance.Applied microbiology and biotechnology · 2022Article
- Effect of 1,3-Beta Glucans Dietary Addition on the Growth, Intestinal Histology, Blood Biochemical Parameters, Immune Response, and Immune Expression of CD3 and CD20 in Broiler Chickens.Animals : an open access journal from MDPI · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study was conducted to estimate the impacts of using varied feeding regimens with or without protease supplementation on the growth performance, apparent amino acid ileal digestibility (AID%), economic efficiency, intestinal histology, and blood biochemical parameters of broiler chickens. Three hundred one-day-old chicks (Ross 308 broiler) were randomly allotted to a 3 × 2 factorial design. The experimental design consisted of three feeding regimens; FR1: a recommended protein SBM diet, FR2: a low-protein SBM diet, and FR3: a low-protein diet with the inclusion of 5% DDGS and 5% SFM, with or without protease supplementation (250 mg/kg).
resultsIncreased feed intake and feed conversion ratio were observed in the FR3 treatment during the starter stage and decreased body weight and body weight gain during the grower stage. However, there was no significant effect of the different feeding regimens, protease supplementation, or interaction on the overall performance. The economic value of diets also remained unaffected by the different feeding regimens, protease supplementation, or interaction. Protease supplementation resulted in lowering the AID% of tryptophan and leucine. Reduced AID% of methionine was evident in the FR2 + VE and FR3 - VE treatments. Histological findings substantiated the FR3 treatment mediated a decrease in the duodenal and jejunal villous height (VH), jejunal villous width (VW), and ileal VW, whereas, increase in the ileal crypt depth (CD). The FR2 + VE treatment reduced the VH:CD ratio in the duodenum. The duodenal CD and the jejunal goblet cell count were reduced as a consequence of protease supplementation. The FR3 + VE treatment documented a rise in duodenal CD, while an increase in the jejunal goblet cell count was observed in the FR3 - VE treatment. The FR3 treatment enhanced the IgM serum levels compared to the FR1 and FR2 treatments. IgM serum levels were also elevated following protease supplementation. FR3 + VE treatment increased IgM serum levels. The highest serum ALP was found in the FR3 treatment, whereas the lowest level was obtained in the FR2 treatment.
conclusionLow-protein SBM-based diets could be used without affecting the birds' growth. Altered morphometric measures of the intestine and increased IgM and ALP levels indicated the low-protein SBM/DDGS-SFM diet-induced damage of the intestinal histoarchitecture and immune system of birds. These different diets and protease supplementation failed to affect economic efficiency positively.
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