ArticleBMC nephrology2021
Risk factors, clinical features and outcome of new-onset acute kidney injury among critically ill patients: a database analysis based on prospective cohort study.
Article in BMC nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- ICU-acquired acute kidney injury in critically ill adults: a retrospective cohort study of risk factors and KDIGO stage dynamics in a Brazilian ICU.Renal failure · 2026Article
- Postoperative Acute Kidney Injury in Cardiovascular Surgery Patients with Prolonged Intensive Care Unit Stay: Impact on Mortality and Outcomes.Brazilian journal of cardiovascular surgery · 2026Article
- Supratherapeutic drug concentration triggers: A novel data-driven approach to assess their value for medication safety surveillance in intensive care.British journal of clinical pharmacology · 2026Article
- Early recognition of sepsis-associated acute kidney injury based on BioBERT-BPNN multimodal clinical data analysis.PloS one · 2026Article
- Article
- Development and validation of a nomogram for predicting acute kidney injury in elderly patients in intensive care unit.Renal failure · 2025Article
- Association between standard base excess and acute kidney injury in intensive care unit patients: a study based on the medical information mart for intensive care database.BMC nephrology · 2025Article
- Machine Learning to Assist in Managing Acute Kidney Injury in General Wards: Multicenter Retrospective Study.Journal of medical Internet research · 2025Article
- Prophylactic proton pump inhibitor usage and new-onset acute kidney injury in critically ill patients: a retrospective analysis.Clinical kidney journal · 2025Article
- Central Venous Pressure as a Predictor of Acute Kidney Injury in Cardiac Surgery: A Systematic Review of Observational Studies.Diagnostics (Basel, Switzerland) · 2025Review
- Factors associated with contrast-associated acute kidney injury in an emergency department: A cohort study in Lebanon.PloS one · 2025Article
- Article
- Development of Acute Kidney Injury Predictor Score in Intensive Care Unit Patients in Padang, Indonesia.Acta medica academica · 2024Observational
- Attributable mortality of acute kidney injury among critically ill patients with sepsis: a multicenter, retrospective cohort study.BMC nephrology · 2024Article
- Incidence of acute kidney injury (AKI) and its impact on patient outcomes among adult hospitalized patients with carbapenem-resistant Gram-negative infections who received targeted treatment with a newer β-lactam or β-lactam/β-lactamase inhibitor-, polymyxin- or aminoglycoside-containing regimen.The Journal of antimicrobial chemotherapy · 2024Observational
- Characteristics, Risk Factors, and Outcomes in Acute Kidney Injury Patients: A Retrospective Cross-Sectional Study, Palestine.TheScientificWorldJournal · 2024Article
- Hospital-Acquired Acute Kidney Injury in Non-Critical Medical Patients in a Developing Country Tertiary Hospital: Incidence and Predictors.International journal of nephrology and renovascular disease · 2024Article
- The attributable mortality of sepsis for acute kidney injury: a propensity-matched analysis based on multicenter prospective cohort study.Renal failure · 2023Article
- The AKI-to-CKD Transition: The Role of Uremic Toxins.International journal of molecular sciences · 2023Review
- Incidence, risk factors and outcomes of acute kidney injury in surgical intensive care unit octogenarians at the Jordan University Hospital.BMC geriatrics · 2023Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute kidney injury (AKI) newly-emerged in intensive care unit (ICU), has not been thoroughly studied in previous researches, is likely to differ from AKI developed before ICU admission. This study aimed to evaluate the incidence, risk factors, clinical features and outcome of new-onset AKI in critically ill patients.
methodsThe data of present study derived from a multicenter, prospective cohort study in17 Chinese ICUs (January 2014 - August 2015). The incidence, risk factors, clinical features and survival analysis of new-onset AKI were assessed.
resultsA total of 3374 adult critically ill patients were eligible. The incidence of new-onset AKI was 30.0 % (n = 1012). Factors associated with a higher risk of new-onset AKI included coronary heart disease, hypertension, chronic liver disease, use of nephrotoxic drugs, sepsis, SOFA score, APACHEII score and use of vasopressors. The new-onset AKI was an independent risk factor for 28-day mortality (adjusted hazard ratio, 1.643; 95 % CI, 1.370-1.948; P < 0.001). 220 (21.7 %) patients received renal replacement therapy (RRT), 71 (32.3 %) of them were successfully weaning from RRT. More than half of the new-onset AKI were transient AKI (renal recovery within 48 h). There was no statistical relationship between transient AKI and 28-day mortality (hazard ratio, 1.406; 95 % CI, 0.840-1.304; P = 0.686), while persistent AKI (non-renal recovery within 48 h) was strongly associated with 28-day mortality (adjusted hazard ratio, 1.486; 95 % CI, 1.137-1.943; P < 0.001).
conclusionsNew-onset AKI is common in ICU patients and is associated with significantly higher 28-day mortality. Only persistent AKI, but not transient AKI is associated with significantly higher 28-day mortality.
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