ArticleStroke2021
Baseline Cognitive Impairment in Patients With Asymptomatic Carotid Stenosis in the CREST-2 Trial.
Article in Stroke, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02089217 (Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial), which is not on this map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Neurotrophin System Alterations Associated with Neurotoxicity Accompanied by Carotid Artery Diseases-A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Recent advances and controversial issues in the optimal management of asymptomatic carotid stenosis.Journal of vascular surgery · 2024Pooled it
- Apixaban Versus Aspirin to Reduce Cognitive Decline After Cryptogenic Stroke and Atrial Cardiopathy: ARCADIA-Cognition Study.Journal of the American Heart Association · 2025Trial
- Article
- Relationship Between Degree of Stenosis and Time-to-Peak Delay in High Grade Asymptomatic Carotid Artery Disease.Stroke · 2026Article
- A cross-sectional study: carotid artery stiffness in individuals with varying cardiovascular disease risk using shear wave elasticity.BMC cardiovascular disorders · 2026Observational
- Article
- A novel composite biomarker score for the identification of cognitive impairment in patients with heart failure: a pilot study.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2025Article
- Adjunctive Human Urinary Kallidinogenase Enhances the Cognitive and Hemodynamic Outcomes of Anterior Circulation Stenting.Translational stroke research · 2025Article
- Simultaneous Luminal and Hemodynamic Evaluation of the Cervical Arteries Using Nonenhanced 3D Quantitative Quiescent-Interval Slice-Selective Magnetic Resonance Angiography.Journal of magnetic resonance imaging : JMRI · 2025Article
- Asymptomatic carotid artery stenosis is associated with increased Alzheimer's disease and non-Alzheimer's disease dementia risk.Stroke and vascular neurology · 2025Article
- Neurofibrillary tangles predict dementia in patients with carotid stenosis.Journal of vascular surgery · 2025Article
- Carotid Revascularization Is Associated With Improved Mood in Patients With Advanced Carotid Disease.Annals of surgery · 2025Article
- Temporal changes and implications of diffusion tensor imaging metrics and cerebral white matter volume in patients undergoing carotid endarterectomy - a prospective study.Neuroradiology · 2025Article
- Impact of carotid artery revascularization on cognitive function: a study of symptomatic and asymptomatic cases.Frontiers in neurology · 2025Article
- Cognitive impairment in asymptomatic carotid artery stenosis is associated with abnormal segments in the Circle of Willis.Journal of vascular surgery · 2024Article
- Unstable Plaque is a Treatable Cause of Cognitive Decline.Medical hypotheses · 2024Article
- William M. Feinberg Lecture: Asymptomatic Carotid Stenosis: Current and Future Considerations.Stroke · 2024Review
- Gray-Scale Median in Patients with Symptomatic and Asymptomatic Carotid Atherosclerosis-Risk Factors and Diagnostic Potential.Biomedicines · 2024Article
- Non-Invasive Tools in Perioperative Stroke Risk Assessment for Asymptomatic Carotid Artery Stenosis with a Focus on the Circle of Willis.Journal of clinical medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 11 institutions in 2 countries.
Funding
Abstract
background and purposeStudies of carotid artery disease have suggested that high-grade stenosis can affect cognition, even without stroke. The presence and degree of cognitive impairment in such patients have not been reported and compared with a demographically matched population-based cohort.
methodsWe studied cognition in 1000 consecutive CREST-2 (Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial) patients, a treatment trial for asymptomatic carotid disease. Cognitive assessment was after randomization but before assigned treatment. The cognitive battery was developed in the general population REGARDS Study (Reasons for Geographic and Racial Differences in Stroke), involving Word List Learning Sum, Word List Recall, and Word List fluency for animal names and the letter F. The carotid stenosis patients were >45 years old with ≥70% asymptomatic carotid stenosis and no history of prevalent stroke. The distribution of cognitive performance for the patients was standardized, accounting for age, race, and education using performance from REGARDS, and after further adjustment for hypertension, diabetes, dyslipidemia, and smoking. Using the Wald Test, we tabulated the proportion of
resultsThere were 786 baseline assessments. Mean age was 70 years, 58% men, and 52% right-sided stenosis. The overall
conclusionsBaseline cognition of patients with severe carotid stenosis showed below normal cognition compared to the population-based cohort, controlling for demographic and cardiovascular risk factors. This cohort represents the largest group to date to demonstrate that poorer cognition, especially memory, in this disease. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02089217.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.