Evidence map›Paper›PMID 34433082›Full record

ArticleCell reports2021

Acute SARS-CoV-2 infection is associated with an increased abundance of bacterial pathogens, including Pseudomonas aeruginosa in the nose.

Nicholas S Rhoades, Amanda N Pinski, Alisha N Monsibais, Allen Jankeel, Brianna M Doratt, Isaac R Cinco, Izabela Ibraim, Ilhem Messaoudi

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Promising Prodiginins Biological Activities.Chemistry & biodiversity · 2025
    Review
  9. Is meningococcal B vaccination needed in the post-COVID-19 world?Biomedica : revista del Instituto Nacional de Salud · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Microorganisms · 2024
    Review
  17. Article
  18. Review
  19. Eco-evolutionary dynamics of experimentalMicrobiology (Reading, England) · 2023
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nicholas S RhoadesDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA.
Amanda N PinskiDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA.
Alisha N MonsibaisDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA.
Allen JankeelDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA.
Brianna M DorattDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA.
Isaac R CincoDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA.
Izabela IbraimDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA.
Ilhem MessaoudiDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA. Electronic address: imessaou@uci.edu.
University of California, Irvine · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Impact of chronic ethanol consumption on lung functional and immunological landscape and implication for susceptibility to SARSCoV2 infectionR01AA028735 · NIAAA · UNIVERSITY OF KENTUCKY · PI MESSAOUDI, ILHEM, VARLAMOV, OLEG · 2020 to 2025
$4.4M
Mechanisms of increased susceptibility to pulmonary Nontuberculous Mycobacterial disease in the elderlyR01AI152258 · NIAID · UNIVERSITY OF KENTUCKY · PI MESSAOUDI, ILHEM · 2020 to 2024
$3.5M
Virus-host interactions: a multi-scale training programT32AI007319 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI SEMLER, BERT L, SHI, YONGSHENG · 1988 to 2024
$2.4M
NCATS NIH HHS UL1 TR001414NCI NIH HHS P30 CA062203NIAAA NIH HHS R01 AA028735NIAID NIH HHS R01 AI152258NIAID NIH HHS T32 AI007319
6 · The paper itself

Abstract

Research conducted on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis and coronavirus disease 2019 (COVID-19) generally focuses on the systemic host response, especially that generated by severely ill patients, with few studies investigating the impact of acute SARS-CoV-2 at the site of infection. We show that the nasal microbiome of SARS-CoV-2-positive patients (CoV

Indexed as

COVID-19MicrobiotaAdultAgedAged, 80 and overBacteriaBacterial InfectionsCoinfectionCross-Sectional StudiesDNA, BacterialFemaleHumansImmunity, InnateInflammationMaleMiddle AgedDNA, BacterialRNA, Ribosomal, 16SRNA, ViralcoinfectionCOVID-19inflammationnasal microbiomePseudomonas aeruginosaRNA-seqSARS-CoV-2viral RNA load

Identifiers

PMID34433082
PMCPMC8361213
OpenAlexW3193495330

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.