Evidence map›Paper›PMID 34433078›Full record

ArticleCurrent biology : CB2021

Transient expression of a GABA receptor subunit during early development is critical for inhibitory synapse maturation and function.

Raunak Sinha, William N Grimes, Julie Wallin, Briana N Ebbinghaus, Kelsey Luu, Timothy Cherry, Fred Rieke, Uwe Rudolph, Rachel O Wong, Mrinalini Hoon

Open access · greenAbstract read
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Region and layer-specific expression of GABAFrontiers in cellular neuroscience · 2024
    Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Raunak SinhaDepartment of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA; McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA.
William N GrimesDepartment of Physiology and Biophysics, University of Washington, Seattle, WA, USA; National Institute of Neurological Disease and Stroke, NIH, Bethesda, MD, USA.
Julie WallinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA; McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA.
Briana N EbbinghausDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA; McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA.
Kelsey LuuCenter for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA, USA.
Timothy CherryCenter for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, University of Washington-Seattle and the Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.
Fred RiekeDepartment of Physiology and Biophysics, University of Washington, Seattle, WA, USA.
Uwe RudolphDepartment of Comparative Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Rachel O WongDepartment of Biological Structure, University of Washington, Seattle, WA, USA.
Mrinalini HoonDepartment of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA; McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: mhoon@wisc.edu.
University of Wisconsin–Madison · USUniversity of Washington · USSeattle Children's Hospital · USUniversity of Illinois Urbana-Champaign · US

Funding

Vision Research CoreP30EY001730 · NEI · UNIVERSITY OF WASHINGTON · PI JAMES Bryant HURLEY · 1985 to 2026
$23.5M
UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI Donna M Peters · 2005 to 2026
$12.6M
INTERCELLULAR COMMUNICATION IN RETINAL DEVELOPMENTR01EY010699 · NEI · WASHINGTON UNIVERSITY · PI WONG, RACHEL O · 1994 to 2024
$8.6M
Neuroscience Training ProgramT32NS105602 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Ari Rosenberg · 2019 to 2026
$2.5M
Retinal interactions between rod and cone signalsR01EY028111 · NEI · UNIVERSITY OF WASHINGTON · PI RIEKE, FREDERICK M · 2017 to 2021
$1.9M
Mechanisms regulating formation and maintenance of sensory circuitsR01EY031677 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI HOON, MRINALINI · 2020 to 2024
$1.9M
Role of synaptic integration in early visual processingR00EY026070 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SINHA, RAUNAK · 2018 to 2020
$747k
Role of synaptic integration in early visual processingK99EY026070 · NEI · UNIVERSITY OF WASHINGTON · PI SINHA, RAUNAK · 2016 to 2017
$180k
NEI NIH HHS K99 EY026070NEI NIH HHS P30 EY001730NEI NIH HHS P30 EY016665NEI NIH HHS R00 EY026070NEI NIH HHS R01 EY010699NEI NIH HHS R01 EY028111NEI NIH HHS R01 EY031677NINDS NIH HHS T32 NS105602
6 · The paper itself

Abstract

Developing neural circuits, including GABAergic circuits, switch receptor types. But the role of early GABA receptor expression for establishment of functional inhibitory circuits remains unclear. Tracking the development of GABAergic synapses across axon terminals of retinal bipolar cells (BCs), we uncovered a crucial role of early GABA

Indexed as

Receptors, GABASynapsesCarrier Proteinsgamma-Aminobutyric AcidPresynaptic TerminalsReceptors, GABA-ARetinal Bipolar CellsCarrier Proteinsgamma-Aminobutyric AcidReceptors, GABAReceptors, GABA-AdevelopmentGABA receptorinhibitory circuitsretinasynapse formation

Identifiers

PMID34433078
PMCPMC8511107
OpenAlexW3195878499

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.