ArticleCell reports2021
Network-centered homeostasis through inhibition maintains hippocampal spatial map and cortical circuit function.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Cell-Type-Specific Synaptic Scaling Mechanisms Differentially Contribute to Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Stra8 links neuronal activity to inhibitory circuit protection in the adult mouse brain.Cell reports · 2025Article
- CA2 neurons show abnormal responses to social stimuli in a rat model of Fragile X syndrome.bioRxiv : the preprint server for biology · 2025Article
- Modulation of primary motor cortex after experimentally induced and use-dependent plasticity in young and older adults.Experimental brain research · 2025Article
- Intrinsic neural diversity quenches the dynamic volatility of neural networks.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Competition on presynaptic resources enhances the discrimination of interfering memories.PNAS nexus · 2023Article
- Stability and learning in excitatory synapses by nonlinear inhibitory plasticity.PLoS computational biology · 2022Article
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Authors and funding
3 authors.
Funding
Abstract
Despite ongoing experiential change, neural activity maintains remarkable stability. Although this is thought to be mediated by homeostatic plasticity, what aspect of neural activity is conserved and how the flexibility necessary for learning and memory is maintained is not fully understood. Experimental studies suggest that there exists network-centered, in addition to the well-studied neuron-centered, control. Here we computationally study such a potential mechanism: input-dependent inhibitory plasticity (IDIP). In a hippocampal model, we show that IDIP can explain the emergence of active and silent place cells as well as remapping following silencing of active place cells. Furthermore, we show that IDIP can also stabilize recurrent dynamics while preserving firing rate heterogeneity and stimulus representation, as well as persistent activity after memory encoding. Hence, the establishment of global network balance with IDIP has diverse functional implications and may be able to explain experimental phenomena across different brain areas.
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Registered trials
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