Evidence map›Paper›PMID 34433025›Full record

ArticleCell reports2021

NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca

Beibei Wu, Jin Seok Woo, Pamela Vila, Marcus Jew, Jennifer Leung, Zuoming Sun, Sonal Srikanth, Yousang Gwack

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. CaJournal of immunology (Baltimore, Md. : 1950) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Beibei WuDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles CA 90095, USA.
Jin Seok WooDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles CA 90095, USA.
Pamela VilaDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles CA 90095, USA.
Marcus JewDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles CA 90095, USA.
Jennifer LeungDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles CA 90095, USA.
Zuoming SunDepartment of Molecular Imaging & Therapy, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
Sonal SrikanthDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles CA 90095, USA. Electronic address: ssrikanth@mednet.ucla.edu.
Yousang GwackDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles CA 90095, USA. Electronic address: ygwack@mednet.ucla.edu.
University of California, Los Angeles · USCity of Hope · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KITCHEN, SCOTT G · 1991 to 2018
$39.9M
Steroid nuclear receptor coactivators in T cell differentiationR01AI109644 · NIAID · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Zuoming Sun · 2014 to 2026
$6.9M
Novel regulators of store-operated Ca2+ entry in immune systemsR01AI083432 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GWACK, YOUSANG · 2009 to 2020
$3.8M
Mechanism underlying regulation of Ca2+ signaling in local effector T cellsR01AI146615 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GWACK, YOUSANG · 2020 to 2024
$1.8M
Regulation of the STING pathway under sterile conditionsR01AI146352 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SRIKANTH, SONAL · 2020 to 2023
$1.6M
Function of TCF-1 in antagonizing malignancyR21AI163256 · NIAID · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SUN, ZUOMING · 2021 to 2022
$484k
Distinctive role of ORAI3 channels in the effector T cell responseR21AI149236 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GWACK, YOUSANG · 2020 to 2021
$429k
Distinct functions of Orai1 and Orai2 in naive and effector helper T cellsR21AI130653 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SRIKANTH, SONAL · 2017 to 2018
$424k
Role of Orai1 trafficking in local effector T cell responsesR56AI146615 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GWACK, YOUSANG · 2019 to 2019
$390k
Development of an animal model of severe neutrophilic asthmaR03AI147063 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GWACK, YOUSANG · 2019 to 2020
$156k
NCI NIH HHS P30 CA016042NIAID NIH HHS P30 AI028697NIAID NIH HHS R01 AI083432NIAID NIH HHS R01 AI109644NIAID NIH HHS R01 AI146352NIAID NIH HHS R01 AI146615NIAID NIH HHS R03 AI147063NIAID NIH HHS R21 AI130653NIAID NIH HHS R21 AI149236NIAID NIH HHS R21 AI163256NIAID NIH HHS R56 AI146615
6 · The paper itself

Abstract

Sustained activation of the Ca

Indexed as

Adaptor Proteins, Signal TransducingCalciumCalcium-Binding ProteinsCalcium ChannelsCalcium SignalingHumansNeoplasm ProteinsORAI1 ProteinT-LymphocytesAdaptor Proteins, Signal TransducingCalciumCalcium-Binding ProteinsCalcium ChannelsNeoplasm ProteinsNKD2 protein, humanORAI1 ProteinORAI1 protein, humanORAI1, STIM1, T cell receptor signaling, NKD2, CRAC channels, effector T cells, store-operated calcium entry, intracellular vesicles

Identifiers

PMID34433025
PMCPMC8435239
OpenAlexW3194686947

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.