Evidence map›Paper›PMID 34433024›Full record

Trial reportCell reports2021

Synchronization patterns reveal neuronal coding of working memory content.

Fahimeh Mamashli, Sheraz Khan, Matti Hämäläinen, Mainak Jas, Tommi Raij, Steven M Stufflebeam, Aapo Nummenmaa, Jyrki Ahveninen

Abstract readClinical Trial
In one paragraph

Trial report in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. [Effects of 40 Hz light flicker stimulation on hippocampal-prefrontal neural activity characteristics during working memory tasks in Alzheimer's disease model rats].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Article
  4. Characterizing Directional Dynamics of Semantic Prediction Based on Inter-regional Temporal Generalization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Theta-Alpha Connectivity in the Hippocampal-Entorhinal Circuit Predicts Working Memory Load.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  14. Article
  15. Article
  16. Maintaining Auditory Working Memory Representations beyond Sensory Cortices Makes Working Memory Work.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Saccade rate is associated with recall of items in working memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fahimeh MamashliAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Bldg. 149 13(th) Street, Charlestown, MA 02129, USA; Department of Radiology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Sheraz KhanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Bldg. 149 13(th) Street, Charlestown, MA 02129, USA; Department of Radiology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Matti HämäläinenAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Bldg. 149 13(th) Street, Charlestown, MA 02129, USA; Department of Radiology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Mainak JasAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Bldg. 149 13(th) Street, Charlestown, MA 02129, USA; Department of Radiology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Tommi RaijAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Bldg. 149 13(th) Street, Charlestown, MA 02129, USA; Department of Radiology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Departments of Physical Medicine and Rehabilitation and Neurobiology, Northwestern University, 710 North Lake Shore Drive, Chicago, IL 60611, USA.
Steven M StufflebeamAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Bldg. 149 13(th) Street, Charlestown, MA 02129, USA; Department of Radiology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Aapo NummenmaaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Bldg. 149 13(th) Street, Charlestown, MA 02129, USA; Department of Radiology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Jyrki AhveninenAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Bldg. 149 13(th) Street, Charlestown, MA 02129, USA; Department of Radiology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Electronic address: jahveninen@mgh.harvard.edu.

Funding

Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Scalable Software for Distributed Processing and Visualization of Multi-Site MEG/EEG DatasetsR01NS104585 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MATTI HAMALAINEN · 2018 to 2026
$4.3M
Mapping the intrinsic functional organization of auditory cortex in individual subjects using 7T MRIR01DC017991 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI AHVENINEN, JYRKI · 2019 to 2023
$4.0M
Decoding parametric attributes of auditory working memories from human brain activityR01DC016915 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI AHVENINEN, JYRKI · 2018 to 2022
$3.0M
Non-invasive measures of multisensory cortical feedforward and feedback influencesR01DC016765 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI AHLFORS, SEPPO PENTTI, AHVENINEN, JYRKI · 2018 to 2022
$2.7M
NIBIB NIH HHS P41 EB015896NIDCD NIH HHS R01 DC016765NIDCD NIH HHS R01 DC016915NIDCD NIH HHS R01 DC017991NINDS NIH HHS R01 NS104585
6 · The paper itself

Abstract

Neuronal oscillations are suggested to play an important role in auditory working memory (WM), but their contribution to content-specific representations has remained unclear. Here, we measure magnetoencephalography during a retro-cueing task with parametric ripple-sound stimuli, which are spectrotemporally similar to speech but resist non-auditory memory strategies. Using machine learning analyses, with rigorous between-subject cross-validation and non-parametric permutation testing, we show that memorized sound content is strongly represented in phase-synchronization patterns between subregions of auditory and frontoparietal cortices. These phase-synchronization patterns predict the memorized sound content steadily across the studied maintenance period. In addition to connectivity-based representations, there are indices of more local, "activity silent" representations in auditory cortices, where the decoding accuracy of WM content significantly increases after task-irrelevant "impulse stimuli." Our results demonstrate that synchronization patterns across auditory sensory and association areas orchestrate neuronal coding of auditory WM content. This connectivity-based coding scheme could also extend beyond the auditory domain.

Indexed as

MagnetoencephalographyAdultAuditory CortexFemaleHumansMaleMemory, Short-TermNeuronsauditoryfunctional connectivitymachine learningmagnetoencephalographyMVPAphase synchronizationworking memory

Identifiers

PMID34433024
PMCPMC8428113

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.