Evidence map›Paper›PMID 34432883›Full record

ArticleImmunology2021

Transcriptomic landscape of skin lesions in cutaneous leishmaniasis reveals a strong CD8

Carlos Henrique Fantecelle, Luciana Polaco Covre, Renan Garcia de Moura, Herbert Leonel de Matos Guedes, Camila Farias Amorim, Phillip Scott, David Mosser, Aloisio Falqueto, Arne N Akbar, Daniel Claudio Oliveira Gomes

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Leishmaniasis.Nature reviews. Disease primers · 2025
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. The Role of Senescent CD8Pathogens (Basel, Switzerland) · 2024
    Article
  16. Review
  17. Article
  18. Lesional senescent CD4Frontiers in immunology · 2024
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Carlos Henrique FantecelleNúcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitoria, Brazil.
Luciana Polaco CovreNúcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitoria, Brazil.
Renan Garcia de MouraNúcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitoria, Brazil.
Herbert Leonel de Matos GuedesInstituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Camila Farias AmorimDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Phillip ScottDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
David MosserDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA.
Aloisio FalquetoDepartamento de Medicina Social, Universidade Federal do Espírito Santo, Vitoria, Brazil.
Arne N AkbarDivision of Medicine, University College London, London, UK.
Daniel Claudio Oliveira GomesNúcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitoria, Brazil.ORCID 0000-0002-0663-0981
Universidade Federal do Espírito Santo · BRUniversity College London · GBUniversity of Pennsylvania · USUniversidade Federal do Rio de Janeiro · BRUniversity of Maryland, College Park · US

Funding

Medical Research Council MR/T015853/1
6 · The paper itself

Abstract

The severity of lesions that develop in patients infected by Leishmania braziliensis is mainly associated with a highly cytotoxic and inflammatory cutaneous environment. Recently, we demonstrated that senescent T and NK cells play a role in the establishment and maintenance of this tissue inflammation. Here, we extended those findings using transcriptomic analyses that demonstrate a strong co-induction of senescence and pro-inflammatory gene signatures in cutaneous leishmaniasis (CL) lesions. The senescence-associated signature was characterized by marked expression of key genes such as ATM, Sestrin 2, p16, p21 and p38. The cell type identification from deconvolution of bulk sequencing data showed that the senescence signature was linked with CD8

Indexed as

TranscriptomeBiomarkersBiopsyCD8-Positive T-LymphocytesComputational BiologyCytokinesDatabases, GeneticDisease SusceptibilityGene Expression ProfilingGene Expression RegulationHumansImmunosenescenceInflammation MediatorsLeishmania braziliensisLeishmaniasis, CutaneousParasite LoadBiomarkersCytokinesInflammation Mediatorscutaneous leishmaniasisimmunopathogenesisimmunosenescenceLeishmania braziliensissenescence-associated secretory phenotype

Identifiers

PMID34432883
PMCPMC8561102
OpenAlexW3195269367

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.