ArticlePLoS computational biology2021
A probabilistic model for the ultradian timing of REM sleep in mice.
Article in PLoS computational biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- Low-dimensional population dynamics in the brainstem gate REM sleep.Nature neuroscience · 2026Article
- Heart rate and sleep history encode ultradian REM sleep timing.Current biology : CB · 2026Article
- A data-driven measure of REM sleep propensity for human and rodent sleep.Frontiers in neuroscience · 2026Article
- Article
- The futuristic manifolds of REM sleep.Journal of sleep research · 2025Review
- Phasic Dopamine Release in the Nucleus Accumbens Influences REM Sleep Timing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Breathtaking dreams: reduced REM phenotype in REM-related sleep apnea.Sleep & breathing = Schlaf & Atmung · 2025Article
- Clock-Sleep Communication.Current molecular medicine · 2025Review
- Editorial: Signaling pathways and brain circuitry underlying circadian rhythms and sleep.Frontiers in neuroscience · 2025Article
- Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM-REM sleep cycle.Nature neuroscience · 2025Article
- Circuit mechanism underlying fragmented sleep and memory deficits in 16p11.2 deletion mouse model of autism.iScience · 2024Article
- Circuit mechanism underlying fragmented sleep and memory deficits in 16p11.2 deletion mouse model of autism.bioRxiv : the preprint server for biology · 2024Article
- Circuit mechanism underlying fragmented sleep and memory deficits in 16p11.2 deletion mouse model of autism.Research square · 2024Article
- Regulation of stress-induced sleep fragmentation by preoptic glutamatergic neurons.Current biology : CB · 2024Article
- Orexin Neurons to Sublaterodorsal Tegmental Nucleus Pathway Prevents Sleep Onset REM Sleep-Like Behavior by Relieving the REM Sleep Pressure.Research (Washington, D.C.) · 2024Article
- Sleep and circadian rhythmicity as entangled processes serving homeostasis.Nature reviews. Neuroscience · 2024Review
- A predictive propensity measure to enter REM sleep.Frontiers in neuroscience · 2024Article
- Prefrontal Cortical Regulation of REM Sleep.Research square · 2023Article
- Prefrontal cortical regulation of REM sleep.Nature neuroscience · 2023Article
- A medullary hub for controlling REM sleep and pontine waves.Nature communications · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
A salient feature of mammalian sleep is the alternation between rapid eye movement (REM) and non-REM (NREM) sleep. However, how these two sleep stages influence each other and thereby regulate the timing of REM sleep episodes is still largely unresolved. Here, we developed a statistical model that specifies the relationship between REM and subsequent NREM sleep to quantify how REM sleep affects the following NREM sleep duration and its electrophysiological features in mice. We show that a lognormal mixture model well describes how the preceding REM sleep duration influences the amount of NREM sleep till the next REM sleep episode. The model supports the existence of two different types of sleep cycles: Short cycles form closely interspaced sequences of REM sleep episodes, whereas during long cycles, REM sleep is first followed by an interval of NREM sleep during which transitions to REM sleep are extremely unlikely. This refractory period is characterized by low power in the theta and sigma range of the electroencephalogram (EEG), low spindle rate and frequent microarousals, and its duration proportionally increases with the preceding REM sleep duration. Using our model, we estimated the propensity for REM sleep at the transition from NREM to REM sleep and found that entering REM sleep with higher propensity resulted in longer REM sleep episodes with reduced EEG power. Compared with the light phase, the buildup of REM sleep propensity was slower during the dark phase. Our data-driven modeling approach uncovered basic principles underlying the timing and duration of REM sleep episodes in mice and provides a flexible framework to describe the ultradian regulation of REM sleep in health and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.