ArticlePLoS neglected tropical diseases2021
A spatio-temporal analysis of scrub typhus and murine typhus in Laos; implications from changing landscapes and climate.
Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Non-linear effects and lag patterns of eco-environmental factors on scrub typhus: a spatiotemporal analysis in Yunnan, China, 2015-2022.Parasites & vectors · 2026Article
- Rickettsial seropositivity in Lao PDR smallholder livestock farms: Implications for animal and human health.One health (Amsterdam, Netherlands) · 2026Article
- Meningoencephalitis in Flea-Borne Typhus: A Report of Two Cases and a Review of CNS Complications.Pathogens (Basel, Switzerland) · 2026Review
- Neglected rickettsial diseases in Southeast Asia: Twenty-five years of progress in surveillance, diagnostics, and clinical research.PLoS neglected tropical diseases · 2026Review
- The Effect of Climate Change on Emergence and Evolution of Zoonotic Diseases in Asia.Zoonoses and public health · 2025Review
- Associations between meteorological factors and scrub typhus incidence: a systematic review and meta-analysis of linear and nonlinear dose-response relationships.Tropical medicine and health · 2025Article
- Distribution and Risk Factors of Scrub Typhus in South Korea, From 2013 to 2019: Bayesian Spatiotemporal Analysis.JMIR public health and surveillance · 2025Article
- Spatiotemporal evolution and impacts of environment on scrub typhus in northern China, 2006-2019.Journal of global health · 2025Article
- Distinguishing Multisystem Inflammatory Syndrome in Children From Typhus Using Artificial Intelligence: MIS-C Versus Endemic Typhus (AI-MET).The Journal of infectious diseases · 2025Article
- Mathematical analysis of scrub typhus seasonal infection with re-scaled transmission rate considering Northeast India reported data from 2010 to 2022.Scientific reports · 2025Article
- Article
- Exploring the influencing factors of scrub typhus in Gannan region, China, based on spatial regression modelling and geographical detector.Infectious Disease Modelling · 2025Article
- A One Health Perspective on the Resurgence of Flea-Borne Typhus in Texas in the 21st Century: Part 1: The Bacteria, the Cat Flea, Urbanization, and Climate Change.Pathogens (Basel, Switzerland) · 2025Article
- Identification of Bacteria and Viruses Associated with Patients with Acute Febrile Illness in Khon Kaen Province, Thailand.Viruses · 2024Article
- Epidemiology of Murine Typhus in Taiwan from 2013 to 2020.The American journal of tropical medicine and hygiene · 2024Article
- Climate influences scrub typhus occurrence in Vellore, Tamil Nadu, India: analysis of a 15-year dataset.Scientific reports · 2024Article
- Molecular epidemiological study of Scrub Typhus in residence, farm and forest habitats from Yunnan Province, China.PloS one · 2024Article
- Murine Typhus: A Review of a Reemerging Flea-Borne Rickettsiosis with Potential for Neurologic Manifestations and Sequalae.Infectious disease reports · 2023Review
- Article
- How meteorological factors impacting on scrub typhus incidences in the main epidemic areas of 10 provinces, China, 2006-2018.Frontiers in public health · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 5 countries.
Funding
Abstract
backgroundScrub typhus (ST) and murine typhus (MT) are common but poorly understood causes of fever in Laos. We examined the spatial and temporal distribution of ST and MT, with the intent of informing interventions to prevent and control both diseases. METHODOLOGY AND PRINCIPLE
findingsThis study included samples submitted from 2003 to 2017 to Mahosot Hospital, Vientiane, for ST and MT investigation. Serum samples were tested using IgM rapid diagnostic tests. Patient demographic data along with meteorological and environmental data from Laos were analysed. Approximately 17% of patients were positive for either ST (1,337/8,150 patients tested) or MT (1,283/7,552 patients tested). While both diseases occurred in inhabitants from Vientiane Capital, from the univariable analysis MT was positively and ST negatively associated with residence in Vientiane Capital. ST was highly seasonal, with cases two times more likely to occur during the wet season months of July-September compared to the dry season whilst MT peaked in the dry season. Multivariable regression analysis linked ST incidence to fluctuations in relative humidity whereas MT was linked to variation in temperature. Patients with ST infection were more likely to come from villages with higher levels of surface flooding and vegetation in the 16 days leading up to diagnosis.
conclusionsThe data suggest that as cities expand, high risk areas for MT will also expand. With global heating and risks of attendant higher precipitation, these data suggest that the incidence and spatial distribution of both MT and ST will increase.
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