Evidence map›Paper›PMID 34432556›Full record

ArticleAutophagy2022

Vitamin D-VDR (vitamin D receptor) regulates defective autophagy in renal tubular epithelial cell in streptozotocin-induced diabetic mice via the AMPK pathway.

Aimei Li, Bin Yi, Hailong Han, Shikun Yang, Zhaoxin Hu, Li Zheng, Jianwen Wang, Qin Liao, Hao Zhang

Open access · bronzeAbstract read
In one paragraph

Article in Autophagy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 128 citations in OpenAlex.

  1. Article
  2. Review
  3. Ubiquitination-Related Diagnostic Biomarkers for Diabetic Nephropathy: Insights From Multiomic Analysis, Drug Docking, and Experimental Validation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Post‑translational modifications in diabetic kidney disease (Review).International journal of molecular medicine · 2026
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Autophagy andFrontiers in cellular and infection microbiology · 2026
    Review
  17. Article
  18. Article
  19. Observational
  20. Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Aimei LiDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID 0000-0001-7908-9391
Bin YiDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hailong HanCentre For Medical Genetics And Hunan Key Laboratory of Medical Genetics, School Of Life Sciences, Central South University, Changsha, Hunan, China.
Shikun YangDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhaoxin HuDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Li ZhengDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jianwen WangDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Qin LiaoDepartment of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hao ZhangDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic nephropathy (DN) has become a major cause of end-stage renal disease, and autophagy disorder is implicated in the pathogenesis of DN. Our previous studies found that vitamin D (VD) and VDR (vitamin D receptor) played a renoprotective role by inhibiting inflammation and fibrosis. However, whether VD-VDR regulates autophagy disorders in DN remains unclear. In this study, we established a streptozotocin (STZ)-induced diabetic model in

Indexed as

Diabetes Mellitus, ExperimentalDiabetic NephropathiesAMP-Activated Protein KinasesAnimalsAutophagyCalcium-Calmodulin-Dependent Protein Kinase KinaseEpithelial CellsFemaleGlucoseHumansInflammationMaleMiceMice, KnockoutReceptors, CalcitriolStreptozocinAMP-Activated Protein KinasesCalcium-Calmodulin-Dependent Protein Kinase KinaseCAMKK2 protein, humanGlucoseReceptors, CalcitriolStreptozocinVDR protein, humanVitamin DVitaminsAMPKautophagydiabetic nephropathyrenal tubular epithelial cellvitamin D receptor

Identifiers

PMID34432556
PMCPMC9037529
OpenAlexW3196133764

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.