Evidence map›Paper›PMID 34432378›Full record

ReviewESC heart failure2021

Pemphigus-associated cardiomyopathy: report of autoimmune myocarditis and review of literature.

Andrea Frustaci, Marco Francone, Romina Verardo, Rossella Scialla, Giulia Bagnato, Maria Alfarano, Cristina Chimenti, Emanuela Frustaci, Luigi Sansone, Matteo Russo

Open access · goldAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Andrea FrustaciDepartment of Clinical, Internal, Anesthesiologist and Cardiovascular Sciences, Sapienza University, Viale del Policlinico 155, Rome, 00161, Italy.
Marco FranconeDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University, Rome, Italy.
Romina VerardoCellular and Molecular Cardiology Lab, IRCCS L. Spallanzani, Rome, Italy.
Rossella SciallaCellular and Molecular Cardiology Lab, IRCCS L. Spallanzani, Rome, Italy.
Giulia BagnatoCellular and Molecular Cardiology Lab, IRCCS L. Spallanzani, Rome, Italy.
Maria AlfaranoDepartment of Clinical, Internal, Anesthesiologist and Cardiovascular Sciences, Sapienza University, Viale del Policlinico 155, Rome, 00161, Italy.
Cristina ChimentiDepartment of Clinical, Internal, Anesthesiologist and Cardiovascular Sciences, Sapienza University, Viale del Policlinico 155, Rome, 00161, Italy.
Emanuela FrustaciCellular and Molecular Cardiology Lab, IRCCS L. Spallanzani, Rome, Italy.
Luigi SansoneLaboratory of Molecular and Cellular Pathology, IRCCS San Raffaele Pisana, Rome, Italy.
Matteo RussoMEBIC Consortium, San Raffaele Open University and IRCCS San Raffaele Pisana, Rome, Italy.
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITPoliclinico Umberto I · ITIRCCS Ospedale San Raffaele · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pemphigus is a rare disease characterized by bullous lesions of the skin and mucous membranes. The aetiology is autoimmune and related to the formation of IgG autoantibodies against desmogleins, which are structural proteins of desmosomes that ensure the stability of contacts between cells. Cardiac involvement in patients with pemphigus is poorly documented. We report the data in the literature on this topic and a case of pemphigus-associated autoimmune myocarditis with damage of intercalated disc responding to immunosuppressive therapy. The occurrence of cardiomyopathy with left ventricular dysfunction in patients affected by pemphigus should be appropriately screened with endomyocardial biopsy as it could be the myocardial extension of a potentially reversible autoimmune disorder.

Indexed as

Autoimmune DiseasesMyocarditisPemphigusAutoantibodiesDesmosomesHumansAutoantibodiesAutoimmune myocarditisCardiomyopathyPemphigus

Identifiers

PMID34432378
PMCPMC8497363
OpenAlexW3193653277

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.