Evidence map›Paper›PMID 34432324›Full record

ArticleJournal of veterinary internal medicine2021

Contrast-enhanced ultrasonography in dogs with inflammatory bowel disease.

Nikolina Linta, Pascaline Pey, Marco Baron Toaldo, Marco Pietra, Manuel Felici, Giuliano Bettini, Mario Cipone, Alessia Diana

Open access · goldAbstract read
In one paragraph

Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Nikolina LintaDepartment of Veterinary Medical Science, Alma Mater Studiorum, University of Bologna, Ozzano Emilia, Italy.
Pascaline PeyDepartment of Veterinary Medical Science, Alma Mater Studiorum, University of Bologna, Ozzano Emilia, Italy.ORCID https://orcid.org/0000-0003-3917-4756
Marco Baron ToaldoDepartment of Veterinary Medical Science, Alma Mater Studiorum, University of Bologna, Ozzano Emilia, Italy.ORCID https://orcid.org/0000-0001-9609-1856
Marco PietraDepartment of Veterinary Medical Science, Alma Mater Studiorum, University of Bologna, Ozzano Emilia, Italy.ORCID https://orcid.org/0000-0003-4431-0791
Manuel FeliciDepartment of Veterinary Medical Science, Alma Mater Studiorum, University of Bologna, Ozzano Emilia, Italy.
Giuliano BettiniDepartment of Veterinary Medical Science, Alma Mater Studiorum, University of Bologna, Ozzano Emilia, Italy.ORCID https://orcid.org/0000-0003-1857-7329
Mario CiponeDepartment of Veterinary Medical Science, Alma Mater Studiorum, University of Bologna, Ozzano Emilia, Italy.
Alessia DianaDepartment of Veterinary Medical Science, Alma Mater Studiorum, University of Bologna, Ozzano Emilia, Italy.ORCID https://orcid.org/0000-0003-1709-3920
University of Bologna · ITANT Foundation Italy Onlus · ITUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundContrast-enhanced ultrasonography (CEUS) is used to evaluate vascularity of the gastrointestinal wall in neoplastic and inflammatory diseases.

objectiveTo assess the feasibility of CEUS for the evaluation of duodenal perfusion in dogs with inflammatory bowel disease (IBD). ANIMALS: Forty-two dogs with IBD and 20 clinically healthy dogs.

methodsAll CEUS studies of the duodenum were analyzed to obtain time-intensity curves and perfusion parameters. The procedure was repeated in 12 IBD dogs 2 months after a standardized treatment.

resultsOn CEUS, the duodenal wall showed a typical perfusion pattern characterized by a radial and simultaneous enhancement of the wall in all dogs. On qualitative assessment, no differences were observed in contrast medium distribution between healthy and affected dogs, or between dogs with IBD before and after treatment. Peak intensity (PI) and area under the curve (AUC) significantly differed between healthy (PI = 3.58 arbitrary units [au; 1.86-4.93 au] and AUC = 47.63 au seconds [aus, 22.68-62.15]) and affected dogs (PI = 5.10 au [0.63-15.16 au] and AUC = 63.62 aus [5.31-212.20 aus]; P = .03 and .03, respectively). No significant differences were found for the perfusion parameters before and after treatment. CONCLUSIONS AND CLINICAL IMPORTANCE: We showed that CEUS allows discrimination between IBD affected dogs and healthy dogs by evaluation of time-intensity curves, but did not provide useful information for monitoring therapeutic response. The qualitative assessment identified no significant differences between healthy and affected dogs, or between dogs before and after treatment.

Indexed as

ColitisDog DiseasesInflammatory Bowel DiseasesAnimalsContrast MediaDogsDuodenumUltrasonographyContrast Mediacaninegastroenterologyimagingintestineultrasound

Identifiers

PMID34432324
PMCPMC8478066
OpenAlexW3193818188

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.