ArticleEndocrine2022
Elevated thyroid-stimulating hormone levels are associated with poor sleep: a cross-sectional and longitudinal study.
Article in Endocrine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Sleep deprivation as a modulator of thyroid function: a systematic review and meta-analysis.Journal of endocrinological investigation · 2026Review
- Sleep aspects and subclinical hypothyroidism: a four-year follow-up of the ELSA-Brasil study.Archives of endocrinology and metabolism · 2026Article
- Nonlinear association between sleep duration and thyroid hormone levels in patients with thyroid cancer.Scientific reports · 2026Article
- Sleep patterns, depression, and incident thyroid diseases: a large cohort study of 371,627 United Kingdom biobank participants.BMC public health · 2026Article
- Narrative overview of possible preventive measures for differentiated thyroid carcinomas.Heliyon · 2025Review
- Prevalence and Associative Analysis of Thyroid Dysfunction in Patients with Obstructive Sleep Apnea Hypopnea Syndrome: A Cross-Sectional Study.Nature and science of sleep · 2025Article
- Analysis of vitamin D metabolism, thyroid and autoimmune markers in the vitiligo pathways and their possible interaction with sleep.Archives of dermatological research · 2024Article
- Role of Iodine Status and Lifestyle Behaviors on Goiter among Children and Adolescents: A Cross-Sectional Study in Zhejiang Province, China.Nutrients · 2024Article
- Review
- The Diagnostic Value of Gut Microbiota Analysis for Post-Stroke Sleep Disorders.Diagnostics (Basel, Switzerland) · 2023Article
- The association between electronic cigarettes, sleep duration, and the adverse cardiovascular outcomes: Findings from behavioral risk factor surveillance system, 2020.Frontiers in cardiovascular medicine · 2022Article
- Association between anti-thyroid peroxidase antibody and insufficient sleep in euthyroid population.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
purposePoor sleep accompanied by elevated TSH (thyroid stimulating hormone) levels is not uncommon since TSH secretion is controlled by the circadian rhythm. However, the relationship between poor sleep and TSH elevation is unclear; hence, we aimed to elucidate this relationship by conducting a cross-sectional and longitudinal study.
methodsParticipants with isolated elevated (N = 168) and normal (N = 119) TSH concentrations were recruited, and the Pittsburgh Sleep Quality Index (PSQI) was used to assess the sleep status. Subjects with an isolated TSH elevation were followed up longitudinally. The serum TSH concentration was remeasured after sleep status improved.
resultsThe proportions of poor sleep and occasional poor sleep in subjects with isolated TSH elevation were significantly higher than those with normal TSH levels (70.24% vs. 49.58%, p = 0.001; 9.52% vs. 1.68%, p = 0.006). Subjects with isolated TSH elevation had significantly higher PSQI scores in the subjective sleep quality, sleep latency, sleep duration, and habitual sleep efficiency dimensions than those with normal TSH levels (all p < 0.05). Poor sleep was significantly associated with isolated TSH elevation in the multiple logistic regression analysis [odds ratio (OR) = 2.396, p = 0.001]. Among subjects with an isolated TSH elevation at baseline, the percentage of TSH normalization was significantly higher in those who slept better than in those who still slept poorly (85.42% vs. 6.45%, p < 0.001).
conclusionsThis study revealed that isolated elevated TSH concentrations normalize when the sleep status is improved; hence, we recommend that clinicians thoroughly assess the sleep status of patients and remeasure TSH concentrations after sleep status improves.
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