Evidence map›Paper›PMID 34432222›Full record

ReviewJournal of the Association for Research in Otolaryngology : JARO2021

Cochlear Implant Research and Development in the Twenty-first Century: A Critical Update.

Robert P Carlyon, Tobias Goehring

Open access · hybridAbstract readHistorical ArticleReview
In one paragraph

Review in Journal of the Association for Research in Otolaryngology : JARO, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Article
  5. Cochlear implantation in children with congenital inner ear anomalies: challenges and outcomes.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. Treating Hearing Loss: From Cochlear Implantation to Gene Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  10. Review
  11. A deep learning framework for understanding cochlear implants.bioRxiv : the preprint server for biology · 2025
    Article
  12. Chronic Auditory-Nerve Implant Enhances Brainstem Phase Locking to Electric Pulse Trains.Journal of the Association for Research in Otolaryngology : JARO · 2025
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. The rise of cochlear gene therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  18. Advancing precision ear medicine: leveraging animal models for disease insights and therapeutic innovations.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Review
  19. Review
  20. Pulse timing dominates binaural hearing with cochlear implants.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Robert P CarlyonCambridge Hearing Group, MRC Cognition & Brain Sciences Unit, University of Cambridge, Cambridge, CB2 7EF, UK. bob.carlyon@mrc-cbu.cam.ac.uk.ORCID 0000-0002-6166-501X
Tobias GoehringCambridge Hearing Group, MRC Cognition & Brain Sciences Unit, University of Cambridge, Cambridge, CB2 7EF, UK.
MRC Cognition and Brain Sciences Unit · GB

Funding

Medical Research Council G101400Medical Research Council MC_UU_00005/3Medical Research Council MR/T03095X/1
6 · The paper itself

Abstract

Cochlear implants (CIs) are the world's most successful sensory prosthesis and have been the subject of intense research and development in recent decades. We critically review the progress in CI research, and its success in improving patient outcomes, from the turn of the century to the present day. The review focuses on the processing, stimulation, and audiological methods that have been used to try to improve speech perception by human CI listeners, and on fundamental new insights in the response of the auditory system to electrical stimulation. The introduction of directional microphones and of new noise reduction and pre-processing algorithms has produced robust and sometimes substantial improvements. Novel speech-processing algorithms, the use of current-focusing methods, and individualised (patient-by-patient) deactivation of subsets of electrodes have produced more modest improvements. We argue that incremental advances have and will continue to be made, that collectively these may substantially improve patient outcomes, but that the modest size of each individual advance will require greater attention to experimental design and power. We also briefly discuss the potential and limitations of promising technologies that are currently being developed in animal models, and suggest strategies for researchers to collectively maximise the potential of CIs to improve hearing in a wide range of listening situations.

Indexed as

Cochlear ImplantationCochlear ImplantsSpeech PerceptionAcoustic StimulationHistory, 20th CenturyHistory, 21st CenturyHumansNoiseCochlear implantsHearingPitchPlasticity

Identifiers

PMID34432222
PMCPMC8476711
OpenAlexW3195373245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.