Evidence map›Paper›PMID 34432219›Full record

ReviewMolecular biology reports2021

Helminth protection against type-1 diabetes: an insight into immunomodulatory effect of helminth-induced infection.

Muhammad Adnan Sabir Mughal, Muhammad Kasib Khan, Zaheer Abbas, Rao Zahid Abbas, Hammad Ur Rehman Bajwa, Abdullah Khalid Chatha, Muhammad Imran, Zia Ud Din Sindhu, Asghar Abbas, Arsalan Zafar and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Muhammad Adnan Sabir MughalEpidemiology Laboratory, Department of Parasitology, University of Agriculture, Faisalabad, 38000, Pakistan.
Muhammad Kasib KhanEpidemiology Laboratory, Department of Parasitology, University of Agriculture, Faisalabad, 38000, Pakistan. mkkhan@uaf.edu.pk.ORCID http://orcid.org/0000-0001-6050-4321
Zaheer AbbasEpidemiology Laboratory, Department of Parasitology, University of Agriculture, Faisalabad, 38000, Pakistan.
Rao Zahid AbbasChemotherapy Laboratory, Department of Parasitology, University of Agriculture, Faisalabad, 38000, Pakistan.
Hammad Ur Rehman BajwaEpidemiology Laboratory, Department of Parasitology, University of Agriculture, Faisalabad, 38000, Pakistan.
Abdullah Khalid ChathaEpidemiology Laboratory, Department of Parasitology, University of Agriculture, Faisalabad, 38000, Pakistan.
Muhammad ImranMolecular Parasitology Laboratory, Department of Parasitology, University of Agriculture, Faisalabad, 38000, Pakistan.
Zia Ud Din SindhuImmuno-Parasitology Laboratory, Department of Parasitology, University of Agriculture, Faisalabad, 38000, Pakistan.
Asghar AbbasFaculty of Veterinary and Animal Sciences, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan.
Arsalan ZafarEpidemiology Laboratory, Department of Parasitology, University of Agriculture, Faisalabad, 38000, Pakistan.
Muhammad NadeemEpidemiology Laboratory, Department of Parasitology, University of Agriculture, Faisalabad, 38000, Pakistan.
University of Faisalabad · PKMuhammad Nawaz Shareef University of Agriculture · PKUniversity of Agriculture Faisalabad · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Helminths are the old dirty friends of humans from decades and may live undetected by the immune system for years in the tissues. They have evolved as good experts at subverting the immune system. Despite of their pathogenicity, they provide protection to their host against certain inflammatory diseases such as diabetes by modulating the immune mechanisms. These parasites are extra-cellular and induce Th2 response which triggers the adaptive immune cells as well as innate immune cells to work synergistically allowing Tregs to work in a toll-like receptor-dependent manure. T-helper cells type-2 also secrete certain anti-inflammatory cytokines including IL-4, IL-10, IL-13 and TGF-β which also provide protection against type-1 diabetes. Several helminths such as T. crassiceps, S. venezuelensis, filarial worms, Schistosoma spp. and T. spiralis have been reported to prevent diabetes in mouse models as well as in some clinical trials. Immunomodulatory talent of helminths is receiving greater attention to prevent diabetes. Herein, an attempt has been made to review and highlight the possible immuno-modulatory mechanisms by which helminths provide protection against diabetes. Moreover, this review also emphasizes on the use of helminth-derived molecules or synthetic derivatives of helminth-antigens in clinical trials to overcome rapidly growing autoimmune disorders including diabetes.

Indexed as

Adaptive ImmunityImmunity, InnateAnimalsAntigens, HelminthCytokinesDiabetes Mellitus, Type 1Disease Models, AnimalHelminthiasisHelminthsHumansMiceTh2 CellsT-Lymphocytes, RegulatoryAntigens, HelminthCytokinesAutoimmunityDiabetesHelminthsImmuno-modulationTregs

Identifiers

PMID34432219
OpenAlexW3193554344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.