ArticleEuropean archives of psychiatry and clinical neuroscience2022
Peripheral biomarkers to predict the diagnosis of bipolar disorder from major depressive disorder in adolescents.
Article in European archives of psychiatry and clinical neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Metabolomics in stress-related disorders: a systematic review and bioinformatics analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Pooled it
- The Dynamic Interplay Between Puberty and Structural Brain Development as a Predictor of Mental Health Difficulties in Adolescence: A Systematic Review.Biological psychiatry · 2024Pooled it
- Differentiation between bipolar disorder and major depressive disorder in adolescents: from clinical to biological biomarkers.Frontiers in human neuroscience · 2023Pooled it
- Peripheral biochemical parameters for discrimination between bipolar disorder and major depressive disorder in female patients of reproductive age: a CRP-stratified exploratory study.BMC psychiatry · 2026Article
- Discrimination of first-onset patients with bipolar disorder or major depressive disorder using screened biochemical parameters.Annals of general psychiatry · 2025Article
- Distinct effects of psychiatric disorder diagnoses and severe emotional dysregulation on matrix metalloproteinase-9, proinflammatory cytokines, and inhibitory control function in adolescents with attention-deficit hyperactivity disorder or first-episode major affective disorders.The international journal of neuropsychopharmacology · 2025Article
- Bipolar disorder at mixed states and major depressive disorder with mixed features differ in peripheral biochemical parameters.BMC psychiatry · 2025Observational
- Serum lactate and LDH are related with theta and gamma activities in bipolar disorder: a band-specific metabolic coupling.Frontiers in psychiatry · 2025Article
- Retinal Optical Coherence Tomography in Bipolar Disorder: A Scoping Review.Neuropsychobiology · 2025Article
- Peripheral biomarkers to differentiate bipolar depression from major depressive disorder: a real-world retrospective study.BMC psychiatry · 2024Article
- Inflammatory mediators in major depression and bipolar disorder.Translational psychiatry · 2024Review
- Higher Levels of C-reactive Protein Are Associated With Higher Cortical Surface Area and Lower Cortical Thickness in Youth With Bipolar Disorder.The international journal of neuropsychopharmacology · 2023Article
- Eye movement indices as predictors of conversion to psychosis in individuals at clinical high risk.European archives of psychiatry and clinical neuroscience · 2023Article
- Clinical features and a prognostic nomogram based on the SEER database for hepatoblastoma, hepatocellular carcinoma, and embryonal sarcoma among children and adolescents.Translational pediatrics · 2023Article
- Establishment of an assistive diagnostic model for schizophrenia with oxidative stress biomarkers.Frontiers in pharmacology · 2023Article
- Decision tree distinguish affective disorder diagnosis from psychotic disorder diagnosis with clinical and lab factors.Heliyon · 2022Article
- Early Diagnosis of Bipolar Disorder Coming Soon: Application of an Oxidative Stress Injury Biomarker (BIOS) Model.Neuroscience bulletin · 2022Article
- Mental health during the COVID-19 pandemic, impact of childhood trauma in psychiatric disorders, and predictable biomarkers for bipolar disorder.European archives of psychiatry and clinical neuroscience · 2022Article
- Biochemical and Endocrine Parameters for the Discrimination and Calibration of Bipolar Disorder or Major Depressive Disorder.Frontiers in psychiatry · 2022Article
- Interleukin-8 and tumor necrosis factor-alpha in youth with mood disorders-A longitudinal study.Frontiers in psychiatry · 2022Article
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Authors and funding
15 authors at 4 institutions in 1 country.
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Abstract
The onset of bipolar disorder (BD) occurs in childhood or adolescence in half of the patients. Early stages of BD usually present depressive episodes, which makes it difficult to be distinguished from major depressive disorder (MDD). Objective biomarkers for discriminating BD from MDD in adolescent patients are limited. We collected basic demographic data and the information of the first blood examination performed after the admission to psychiatry unit of BD and MDD inpatients during 2009-2018. We recruited 261 adolescents (aged from 10 to 18), including 160 MDD and 101 BD. Forward-Stepwise Selection of binary logistic regression was used to construct predictive models for the total sample and subgroups by gender. Independent external validation was made by 255 matched patients from another hospital in China. Regression models of total adolescents, male and female subgroups showed accuracy of 73.3%, 70.6% and 75.2%, with area under curves (AUC) as 0.785, 0.816 and 0.793, respectively. Age, direct bilirubin (DBIL), lactic dehydrogenase (LDH), free triiodothyronine (FT3) and C-reactive protein (CRP) were final factors included into the models. The discrimination was well at external validation (AUC = 0.714). This study offers the evidence that accessible information of common clinical laboratory examination might be valuable in distinguishing BD form MDD in adolescents. With good diagnostic accuracies and external validation, the total regression equation might potentially be applied to individualized clinical inferences on adolescent BD patients.
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