Evidence map›Paper›PMID 34432118›Full record

ReviewEuropean journal of nuclear medicine and molecular imaging2021

Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic imaging.

Yan Li, Daniel B Vigneron, Duan Xu

Abstract readReview
In one paragraph

Review in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. SABRE Ir-IMes Catalysis for the Masses.Molecules (Basel, Switzerland) · 2025
    Article
  5. Article
  6. DynamicMagnetic resonance in medicine · 2024
    Article
  7. Article
  8. Article
  9. Hyperpolarized [2-NeuroImage · 2023
    Article
  10. Article
  11. Review
  12. New technologies-the best is yet to come.European journal of nuclear medicine and molecular imaging · 2021
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yan LiDepartment of Radiology and Biomedical Imaging, UCSF Radiology, University of California, 185 Berry Street, Ste 350, Box 0946, San Francisco, CA, 94107, USA. yan.li@ucsf.edu.ORCID http://orcid.org/0000-0002-8413-9311
Daniel B VigneronDepartment of Radiology and Biomedical Imaging, UCSF Radiology, University of California, 185 Berry Street, Ste 350, Box 0946, San Francisco, CA, 94107, USA.
Duan XuDepartment of Radiology and Biomedical Imaging, UCSF Radiology, University of California, 185 Berry Street, Ste 350, Box 0946, San Francisco, CA, 94107, USA.

Funding

Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang · 2002 to 2026
$57.4M
Project 4: Multi-modality Metabolic Imaging for Monitoring Molecular Sub-types of GliomaP01CA118816 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang, Janine Marie Lupo · 2007 to 2026
$44.7M
TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
NCI NIH HHS P01 CA118816NCI NIH HHS P50 CA097257NIBIB NIH HHS P41 EB013598
6 · The paper itself

Abstract

The ability of hyperpolarized carbon-13 MR metabolic imaging to acquire dynamic metabolic information in real time is crucial to gain mechanistic insights into metabolic pathways, which are complementary to anatomic and other functional imaging methods. This review presents the advantages of this emerging functional imaging technology, describes considerations in clinical translations, and summarizes current human brain applications. Despite rapid development in methodologies, significant technological and physiological related challenges continue to impede broader clinical translation.

Indexed as

Magnetic Resonance ImagingPyruvic AcidBrainCarbon IsotopesHumansCarbon-13Carbon IsotopesPyruvic AcidCarbon-13HyperpolarizedLactateMetabolic imagingPyruvate

Identifiers

PMID34432118
PMCPMC8566394

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.