Evidence map›Paper›PMID 34432112›Full record

ReviewCurrent microbiology2021

The Role of Essential Oils in the Inhibition of Efflux Pumps and Reversion of Bacterial Resistance to Antimicrobials.

Maria Anndressa Alves Agreles, Iago Dillion Lima Cavalcanti, Isabella Macário Ferro Cavalcanti

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. The applications and mechanisms ofFrontiers in pharmacology · 2024
    Review
  14. Antibacterial Activity of the Essential Oil ofPlants (Basel, Switzerland) · 2023
    Article
  15. Antibacterial Effect of 16 Essential Oils and Modulation ofAntibiotics (Basel, Switzerland) · 2023
    Article
  16. Synergistic and Antibiofilm Effects of the Essential Oil fromPharmaceuticals (Basel, Switzerland) · 2022
    Article
  17. Article
  18. Molecules (Basel, Switzerland) · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maria Anndressa Alves AgrelesLaboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Av. Prof. Moraes Rego, 1235, Cidade Universitária, Recife, Pernambuco, CEP: 50670-901, Brazil.ORCID http://orcid.org/0000-0002-3795-9050
Iago Dillion Lima CavalcantiLaboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Av. Prof. Moraes Rego, 1235, Cidade Universitária, Recife, Pernambuco, CEP: 50670-901, Brazil.ORCID http://orcid.org/0000-0001-6625-8395
Isabella Macário Ferro CavalcantiLaboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Av. Prof. Moraes Rego, 1235, Cidade Universitária, Recife, Pernambuco, CEP: 50670-901, Brazil. isabella.cavalcanti@ufpe.br.ORCID http://orcid.org/0000-0002-7889-3502

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to the deaths from infections caused by multidrug-resistant microorganisms worldwide, the World Health Organization considers antibiotic resistance to be a critical global public health problem. Bacterial resistance mechanisms are diverse and can be acquired through the overexpression of transmembrane proteins that are called efflux pumps, which act by expelling drugs from the intracellular environment, thereby preventing their action and contributing to the severity of infections. Efflux pumps are one of the main mechanisms of bacterial resistance, and it is important to identify new molecules that are capable of inhibiting the action of efflux pumps and circumvent the problem of resistance linked to the expression of these transmembrane proteins. The plants are promising candidates for obtaining biologically active substances, such as essential oils, with antimicrobial activity and inhibitors of efflux pumps, which can help in the resensitization of bacterial strains resistant to antibiotics. Therefore, this review aims to present the recently reported inhibitory activity of essential oils against bacterial pathogens that produce efflux pumps.

Indexed as

Anti-Infective AgentsBacterial InfectionsOils, VolatileAnti-Bacterial AgentsBacterial ProteinsDrug Resistance, Multiple, BacterialHumansAnti-Bacterial AgentsAnti-Infective AgentsBacterial ProteinsOils, Volatile

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.