Evidence map›Paper›PMID 34432101›Full record

Observational studyAnnals of hematology2021

Circulating miRNAs and tissue iron overload in transfusion-dependent β-thalassemia major: novel predictors and follow-up guide.

Nashwa El-Khazragy, Safa Matbouly, Demiana H Hanna, Nievin Ahmed Mahran, Sally Abdallah Mostafa, Bassam A Abdelrehim, Yasmeen K Farouk, Soha Abuelela

Erratum issuedAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Annals of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Nashwa El-KhazragyClinical Pathology-Hematology Department, Faculty of Medicine Ain Shams Research Institute (MASRI), Ain Shams University, Abbassia, 11566, Cairo, Egypt. nashwaelkhazragy@med.asu.edu.eg.ORCID http://orcid.org/0000-0001-6646-4674
Safa MatboulyPediatrics Hematology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Demiana H HannaBiochemistry Department, Faculty of Science, Cairo University, Cairo, Egypt.
Nievin Ahmed MahranBiochemistry Department, Faculty of Dentistry, Sinai University, Kantara, Egypt.
Sally Abdallah MostafaMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Bassam A AbdelrehimFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), Giza, Egypt.
Yasmeen K FaroukFaculty of Biotechnology, October University for Modern Sciences and Arts (MSA), Giza, Egypt.
Soha AbuelelaClinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ain Shams University · EGOctober University of Modern Sciences and Arts · EGCairo University · EGMansoura University · EGSinai University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue iron overload is a life-threatening scenario in children with transfusion-dependent β-thalassemia major, miRNAs that are involved in iron hemostasis could serve as therapeutic targets for control of iron overload. We aimed to find out the association between three iron-related miRNAs "miR-let-7d, miR-122, and miR-200b" and excess iron in tissues, in transfusion-dependent β-thalassemia major patients. Circulating miRNA expressions are measured in peripheral blood (PB) samples using qPCR of transfusion-dependent (TDT) β-thalassemia patients (n = 140) and normalized to non-transfusion-dependent (NTDT) β-thalassemia (n = 45). Results revealed that plasma expression levels of miR-let-7d and miR-200b were significantly downregulated in TDT patients; however, miR-122 was upregulated. In terms of tissue iron load, aberrant expression of miRNAs was significantly associated with increased-iron accumulation in hepatic and cardiac tissues. We concluded that circulating miRNAs are strong candidates that associate iron hemostasis in transfusion-dependent β-thalassemia major patients. And by extension, targeting miR-let-7d, miR-122, and miR-200 might serve as novel sensitive, specific and non-invasive predictor biomarkers for cellular damage under condition of tissue iron excess.

Indexed as

Adolescentbeta-ThalassemiaBlood TransfusionCase-Control StudiesChildChild, PreschoolFemaleHumansIron OverloadMaleMicroRNAsMicroRNAsMIRN122 microRNA, humanMIRN200 microRNA, humanmirnlet7 microRNA, humanBlood transfusionCirculating miRNAsIron overloadβ-Thalassemia

Identifiers

PMID34432101
OpenAlexW3193550107

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.