ArticleSleep2022
Altered cerebrocerebellar functional connectivity in patients with obstructive sleep apnea and its association with cognitive function.
Article in Sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Reduced cerebral blood flow in obstructive sleep apnea: A meta-analysis of SPECT and MRI studies.Sleep & breathing = Schlaf & Atmung · 2026Pooled it
- Obstructive sleep apnea and attention deficits: A systematic review of magnetic resonance imaging biomarkers and neuropsychological assessments.Brain and behavior · 2023Pooled it
- Intermittent Hypoxemia and Brain Injury Biomarker S100B in Preterm Infants.medRxiv : the preprint server for health sciences · 2025Article
- Hypoxia's Impact on Hippocampal Functional Connectivity: Insights from Resting-State fMRI Studies.Brain sciences · 2025Review
- Effects of Sleep-Disordered Breathing on Daytime Brain Activity in Community-Dwelling Older Adults.Sleep science (Sao Paulo, Brazil) · 2025Article
- Reduced Oxygen Extraction Fraction as a Biomarker for Cognitive Deficits in Obstructive Sleep Apnea.Brain and behavior · 2025Article
- Investigating the impact of type 2 diabetes mellitus on brain function in obstructive sleep apnea patients using regional homogeneity and seed-based functional connectivity methods.Frontiers in neuroscience · 2025Article
- Machine Learning Classification Based on Individual Whole-Brain Functional Connectivity in Male OSA Patients.Nature and science of sleep · 2025Article
- Intrinsic prefrontal functional connectivity according to cognitive impairment in patients with end-stage renal disease.Kidney research and clinical practice · 2024Article
- Abnormal dynamic functional connectivity and topological properties of cerebellar network in male obstructive sleep apnea.CNS neuroscience & therapeutics · 2024Article
- Altered Density of Resting-State Long- and Short-Range Functional Connectivity in Patients with Moderate-to-Severe Obstructive Sleep Apnea.Nature and science of sleep · 2024Article
- Compensatory mechanisms of reduced interhemispheric EEG connectivity during sleep in patients with apnea.Scientific reports · 2023Article
- What Is the Involvement of the Cerebellum During Sleep?Neurology · 2023Article
- White matter microstructure and connectivity changes after surgery in male adults with obstructive sleep apnea: recovery or reorganization?Frontiers in neuroscience · 2023Article
- Classification of severe obstructive sleep apnea with cognitive impairment using degree centrality: A machine learning analysis.Frontiers in neurology · 2022Article
- Inherent regional brain activity changes in male obstructive sleep apnea with mild cognitive impairment: A resting-state magnetic resonance study.Frontiers in aging neuroscience · 2022Article
- Abnormal dynamic functional network connectivity in male obstructive sleep apnea with mild cognitive impairment: A data-driven functional magnetic resonance imaging study.Frontiers in aging neuroscience · 2022Article
- Dynamic regional homogeneity alterations and cognitive impairment in patients with moderate and severe obstructive sleep apnea.Frontiers in neuroscience · 2022Article
- Abnormal Spontaneous Brain Activity and Cognitive Impairment in Obstructive Sleep Apnea.Nature and science of sleep · 2022Article
- The Effects of CPAP Treatment on Resting-State Network Centrality in Obstructive Sleep Apnea Patients.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
STUDY
objectivesPrevious functional MRI studies have reported altered brain networks in patients with obstructive sleep apnea (OSA). However, the extent and pattern of abnormal connectivity were inconsistent across studies, and cerebrocerebellar connections have been rarely assessed. We investigated functional network changes in cerebral and cerebellar cortices of OSA patients.
methodsResting-state functional MRI, polysomnography, and neuropsychological (NP) test data were acquired from 74 OSA patients (age: 45.8 ± 10.7 years) and 33 healthy subjects (39.6 ± 9.3 years). Connectivity matrices were extracted by computing correlation coefficients from various regions of interest, and Fisher r-to-z transformations. In the functional connections that showed significant group differences, linear regression was conducted to examine the association between connectivity and clinical characteristics.
resultsPatients with OSA showed reduced functional connectivity (FC) in cerebrocerebellar connections linking different functional networks, and greater FC in cortical between-network connections in prefrontal regions involving the default mode network (DMN) and the control network. For OSA group, we found no correlation between FC and sleep parameters including lowest SaO2 and arousal index in the connections where significant associations were observed in healthy subjects. FC changes in DMN areas were related to reduced verbal fluency in OSA. Lower local efficiency and lower clustering coefficient of the salience network in the left cerebellum were also observed in OSA.
conclusionsOSA affects mainly the cerebrocerebellar pathway. The disruption of function in these connections are related to sleep fragmentation and hypoxia during sleep. These abnormal network functions, especially DMN, are suggested to participate in cognitive decline of OSA.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.