ArticleEuropean heart journal. Cardiovascular Imaging2022
Novel insights into the athlete's heart: is myocardial work the new champion of systolic function?
Article in European heart journal. Cardiovascular Imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Echocardiographic Parameters and Athlete Performance: Associations and Training Profile Comparisons.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Noninvasive biventricular pressure-strain-volume loop-derived myocardial work analysis in competitive athletes.Scientific reports · 2026Article
- Correlation between myocardial work indices and main echocardiographic and cardiopulmonary exercise stress test parameters in Olympic endurance athletes.European journal of applied physiology · 2025Article
- Cardiac adaptations in young triathletes: a 9-month longitudinal study during the peak height velocity period.European journal of applied physiology · 2025Article
- Non-invasive myocardial work as an independent predictor of postprocedural NT-proBNP in elderly patients undergoing transcatheter aortic valve replacement.GeroScience · 2025Article
- The impact of hypercortisolism beyond metabolic syndrome on left ventricular performance: a myocardial work analysis.Cardiovascular diabetology · 2025Article
- Left ventricular hypertrophy and myocardial work in amateur marathon runners.Frontiers in cardiovascular medicine · 2025Article
- Effect of exercise training on cardiac function and glucose metabolism in the ischemic border zone: insights from multi-modal imaging techniques.Frontiers in cardiovascular medicine · 2025Article
- Artificial intelligence-enabled reconstruction of the right ventricular pressure curve using the peak pressure value: a proof-of-concept study.European heart journal. Imaging methods and practice · 2024Article
- Changes in Cardiopulmonary Capacity Parameters after Surgery: A Pilot Study Exploring the Link between Heart Function and Knee Surgery.Journal of functional morphology and kinesiology · 2024Article
- The effects of mitral stenosis on right ventricular mechanics assessed by three-dimensional echocardiography.Scientific reports · 2024Article
- Right Ventricular Structure and Function in Adolescent Athletes: A 3D Echocardiographic Study.International journal of sports medicine · 2024Article
- Effect of maximum exercise on left ventricular deformation and its correlation with cardiopulmonary exercise capacity in competitive athletes.Echo research and practice · 2023Article
- Mitral and Tricuspid Valve Disease in Athletes.Journal of clinical medicine · 2023Review
- Athlete's Heart: A Cardiovascular Step-By-Step Multimodality Approach.Reviews in cardiovascular medicine · 2023Review
- Experimental research on the evaluation of left ventricular systolic function by layered speckle tracking before and after berberine treatment in a cardiac hypertrophy rat model.Cardiovascular diagnosis and therapy · 2023Article
- Time domain adaptation of left ventricular diastolic intraventricular pressure in elite female ice hockey athletes.Frontiers in cardiovascular medicine · 2023Article
- Changes in cardiac function following a speed ascent to the top of Europe at 4808 m.European journal of applied physiology · 2022Article
- Left ventricular performance by work and wasted energy: is strain not sufficient?European heart journal. Cardiovascular Imaging · 2022Article
- Myocardial inefficiency is an early indicator of exercise-induced myocardial fatigue.Frontiers in cardiovascular medicine · 2022Article
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsWe sought to investigate the correlation between speckle-tracking echocardiography (STE)-derived myocardial work (MW) and invasively measured contractility in a rat model of athlete's heart. We also assessed MW in elite athletes and explored its association with cardiopulmonary exercise test (CPET)-derived aerobic capacity. METHODS AND
resultsSixteen rats underwent a 12-week swim training program and were compared to controls (n = 16). STE was performed to assess global longitudinal strain (GLS), which was followed by invasive pressure-volume analysis to measure contractility [slope of end-systolic pressure-volume relationship (ESPVR)]. Global MW index (GMWI) was calculated from GLS curves and left ventricular (LV) pressure recordings. In the human investigations, 20 elite swimmers and 20 healthy sedentary controls were enrolled. GMWI was calculated through the simultaneous evaluation of GLS and non-invasively approximated LV pressure curves at rest. All subjects underwent CPET to determine peak oxygen uptake (VO2/kg). Exercised rats exhibited higher values of GLS, GMWI, and ESPVR than controls (-20.9 ± 1.7 vs. -17.6 ± 1.9%, 2745 ± 280 vs. 2119 ± 272 mmHg·%, 3.72 ± 0.72 vs. 2.61 ± 0.40 mmHg/μL, all PExercise < 0.001). GMWI correlated robustly with ESPVR (r = 0.764, P < 0.001). In humans, regular exercise training was associated with decreased GLS (-17.6 ± 1.5 vs. -18.8 ± 0.9%, PExercise = 0.002) but increased values of GMWI at rest (1899 ± 136 vs. 1755 ± 234 mmHg·%, PExercise = 0.025). GMWI exhibited a positive correlation with VO2/kg (r = 0.527, P < 0.001).
conclusionsGMWI precisely reflected LV contractility in a rat model of exercise-induced LV hypertrophy and captured the supernormal systolic performance in human athletes even at rest. Our findings endorse the utilization of MW analysis in the evaluation of the athlete's heart.
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