Evidence map›Paper›PMID 34431894›Full record

ArticleArquivos brasileiros de oftalmologia2021

TXNRD2 (rs35934224) CT genotype as possible protective marker for primary open-angle glaucoma in a Brazilian population.

Artur Lins Tenório, Rodrigo Pessoa Cavalcanti Lira, Rodrigo Feliciano do Carmo, Roberto Pedrosa Galvão Filho, Pedro Teixeira Falcão Neto, Rinalva Tenório Vaz, Raul Emidio de Lima, André Lins Tenório, Luydson Richardson Vasconcelos

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In one paragraph

Article in Arquivos brasileiros de oftalmologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Artur Lins TenórioPrograma de Pós-graduação em Cirurgia, Universidade Federal de Pernambuco, Recife, PE, Brazil.ORCID 0000-0001-9194-9243
Rodrigo Pessoa Cavalcanti LiraPrograma de Pós-graduação em Cirurgia, Universidade Federal de Pernambuco, Recife, PE, Brazil.ORCID 0000-0002-7274-1065
Rodrigo Feliciano do CarmoUniversidade Federal do Vale do São Francisco, Petrolina, PE, Brazil.
Roberto Pedrosa Galvão FilhoInstituto de Olhos do Recife, Recife, PE, Brazil.
Pedro Teixeira Falcão NetoInstituto de Olhos do Recife, Recife, PE, Brazil.
Rinalva Tenório VazHospital de Olhos Santa Luzia, Recife, PE, Brazil.
Raul Emidio de LimaInstituto Aggeu Magalhães, Campus da Universidade Federal de Pernambuco, Recife, PE, Brazil.
André Lins TenórioFaculdade de Ciências Médicas, Universidade de Pernambuco, Recife, PE, Brazil.
Luydson Richardson VasconcelosInstituto Aggeu Magalhães, Campus da Universidade Federal de Pernambuco, Recife, PE, Brazil.
Universidade de Pernambuco · BRUniversidade Federal do Vale do São Francisco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the association of the single-nucleotide polymorphism rs35934224 in the TXNRD2 gene with primary open-angle glaucoma in a Brazilian population.

methodsThis was a cross-sectional study conducted to verify the association between the rs35934224 TXNRD2 (thioredoxin reductase 2) and primary open-angle glaucoma in a population from the Northeast region of Brazil. A total of 184 individuals were enrolled, including 94 with primary open-angle glaucoma (45 men and 49 women) and 94 controls (40 men and 54 women) from the Recife Eye Institute.

resultsThe mean age was 68.85 years for the patients with glaucoma and 68.55 years for the controls. Genomic DNA was isolated using commercially available kits, and single-nucleotide polymorphism was detected with real-time polymerase chain reaction using TaqMan probes. The studied population was in Hardy-Weinberg equilibrium. The CT genotype was associated with protection against primary open-angle glaucoma (p=0.022).

conclusionOur data suggest an association between TXNRD2 gene polymorphism (rs35934224) with primary open-angle glaucoma in an admixed Brazilian po pulation. This is the first study to investigate this single-nucleo tide polymorphism in Latin American individuals with primary open-angle glaucoma.

Indexed as

Glaucoma, Open-AngleAgedBrazilCross-Sectional StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansMalePolymorphism, Single NucleotideThioredoxin Reductase 2Tomography, X-Ray ComputedThioredoxin Reductase 2TXNRD2 protein, human

Identifiers

PMID34431894
PMCPMC11826578
OpenAlexW3173472531

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.