Evidence map›Paper›PMID 34431762›Full record

ArticleMicrobial genomics2021

Evolution and emergence of multidrug-resistant

Tyler S Brown, Vegard Eldholm, Ola Brynildsrud, Magnus Osnes, Natalie Levy, James Stimson, Caroline Colijn, Sofia Alexandru, Ecaterina Noroc, Nelly Ciobanu and 3 more

Abstract read
In one paragraph

Article in Microbial genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Multidrug-resistant tuberculosis.Nature reviews. Disease primers · 2024
    Review
  5. Identification of positively selected genes inFrontiers in microbiology · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tyler S BrownInfectious Disease Division, Massachusetts General Hospital, Boston, MA, USA.
Vegard EldholmDivision of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway.
Ola BrynildsrudDivision of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway.
Magnus OsnesDivision of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway.
Natalie LevyDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
James StimsonNational Infection Service, Public Health England, London, UK.
Caroline ColijnDepartment of Mathematics, Simon Fraser University, Vancouver, Canada.
Sofia AlexandruPhthisiopneumology Institute, Chisinau, Republic of Moldova.
Ecaterina NorocPhthisiopneumology Institute, Chisinau, Republic of Moldova.
Nelly CiobanuPhthisiopneumology Institute, Chisinau, Republic of Moldova.
Valeriu CruduPhthisiopneumology Institute, Chisinau, Republic of Moldova.
Ted CohenDepartment of Epidemiology (Microbial Diseases), Yale University School of Public Health, New Haven, CT, USA.
Barun MathemaDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMST32AI007061 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 1985 to 2026
$12.1M
NCATS NIH HHS UL1 TR001863NIAID NIH HHS T32 AI007061
6 · The paper itself

Abstract

The evolution and emergence of drug-resistant tuberculosis (TB) has been studied extensively in some contexts, but the ecological drivers of these two processes remain poorly understood. This study sought to describe the joint evolutionary and epidemiological histories of a novel multidrug-resistant

Indexed as

Evolution, MolecularBayes TheoremDrug Resistance, Multiple, BacterialFemaleGenomicsHumansMaleMoldovaMolecular EpidemiologyMutationMycobacterium tuberculosisPhylogenyPrevalenceTuberculosis, Multidrug-ResistantWhole Genome Sequencingantimicrobial resistanceepidemiologyMycobacterium tuberculosisoutbreaksphylogenomics

Identifiers

PMID34431762
PMCPMC8549355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.