Evidence map›Paper›PMID 34431696›Full record

ArticlemSphere2021

Machine Learning of Bacterial Transcriptomes Reveals Responses Underlying Differential Antibiotic Susceptibility.

Anand V Sastry, Nicholas Dillon, Amitesh Anand, Saugat Poudel, Ying Hefner, Sibei Xu, Richard Szubin, Adam M Feist, Victor Nizet, Bernhard Palsson

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Antibiotic resistance inFrontiers in microbiology · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Anand V Sastry *Department of Bioengineering, University of California-San Diego, La Jolla, California, USA.
Nicholas Dillon *Department of Pediatrics, University of California-San Diego, La Jolla, California, USA.
Amitesh AnandDepartment of Bioengineering, University of California-San Diego, La Jolla, California, USA.
Saugat PoudelDepartment of Bioengineering, University of California-San Diego, La Jolla, California, USA.
Ying HefnerDepartment of Bioengineering, University of California-San Diego, La Jolla, California, USA.
Sibei XuDepartment of Bioengineering, University of California-San Diego, La Jolla, California, USA.
Richard SzubinDepartment of Bioengineering, University of California-San Diego, La Jolla, California, USA.
Adam M FeistDepartment of Bioengineering, University of California-San Diego, La Jolla, California, USA.
Victor NizetDepartment of Pediatrics, University of California-San Diego, La Jolla, California, USA.
Bernhard PalssonDepartment of Bioengineering, University of California-San Diego, La Jolla, California, USA.
University of California San Diego · USNovo Nordisk Foundation · DKThe University of Texas at Dallas · US

Funding

Systems Biology Approach to Redefine Susceptibility Testing and Treatment of MDR Pathogens in the Context of Host ImmunityU01AI124316 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PALSSON, BERNHARD O · 2016 to 2020
$10.2M
Surprising Efficacy of Discounted Antibiotics vs. MDR Gram-Negative Pathogens Occurring Through Innate Immune SensitizationR01AI145310 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KUMARASWAMY, MONIKA, NIZET, VICTOR · 2020 to 2023
$1.9M
Developing Pediatric Clinical Pharmacologists for the Advancement of TherapeuticsT32HD087978 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR, TREMOULET, ADRIANA H · 2016 to 2025
$1.5M
NIAID NIH HHS R01 AI145310NIAID NIH HHS U01 AI124316NICHD NIH HHS T32 HD087978
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Machine LearningTranscriptomeAnti-Bacterial AgentsCulture MediaDrug Resistance, BacterialEscherichia coli K12Gene Expression ProfilingGene Expression Regulation, BacterialHumansIronMicrobial Sensitivity TestsAnti-Bacterial AgentsCulture MediaIronantibioticsindependent component analysisiron regulationmachine learningRNA-seqtranscriptional regulation

Identifiers

PMID34431696
PMCPMC8386450
OpenAlexW3195162687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.