Evidence map›Paper›PMID 34431613›Full record

ArticleUnited European gastroenterology journal2021

The impact of colectomy on the course of extraintestinal manifestations in Swiss inflammatory bowel disease cohort study patients.

René Roth, Stephan Vavricka, Michael Scharl, Philipp Schreiner, Ekaterina Safroneeva, Thomas Greuter, Jonas Zeitz, Benjamin Misselwitz, Alain Schoepfer, Mamadou Pathé Barry and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in United European gastroenterology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

René RothDepartment of Gastroenterology, University Hospital Zurich (USZ), University of Zurich, Zurich, Switzerland.ORCID 0000-0001-5199-8518
Stephan VavrickaCenter for Gastroenterology and Hepatology, Zurich, Switzerland.
Michael ScharlDepartment of Gastroenterology, University Hospital Zurich (USZ), University of Zurich, Zurich, Switzerland.
Philipp SchreinerDepartment of Gastroenterology, University Hospital Zurich (USZ), University of Zurich, Zurich, Switzerland.
Ekaterina SafroneevaInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Thomas GreuterDepartment of Gastroenterology, University Hospital Zurich (USZ), University of Zurich, Zurich, Switzerland.
Jonas ZeitzCenter of Gastroenterology, Clinic Hirslanden, Zurich, Switzerland.
Benjamin MisselwitzDepartment of Gastroenterology, University Hospital Zurich (USZ), University of Zurich, Zurich, Switzerland.
Alain SchoepferDivision of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne, Lausanne, Switzerland.
Mamadou Pathé BarryCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
Gerhard RoglerDepartment of Gastroenterology, University Hospital Zurich (USZ), University of Zurich, Zurich, Switzerland.
Luc BiedermannDepartment of Gastroenterology, University Hospital Zurich (USZ), University of Zurich, Zurich, Switzerland.
Swiss IBD cohort study
University of Zurich · CHCenter for Pediatric Endocrinology Zurich · CHCentre universitaire de médecine générale et santé publique, Lausanne · CHKlinik Hirslanden · CHUniversity Hospital of Lausanne · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsExtraintestinal manifestations are reported to occur in up to 45% of inflammatory bowel disease (IBD) patients during the course of disease. It is unknown whether colectomy reduces the rate of de novo extraintestinal manifestations (EIMs) or impacts on severity of EIMs following a parallel versus independent disease course from underlying IBD.

methodsUsing data from the Swiss Inflammatory Bowel Disease Cohort Study we aimed to analyse the course of EIMs in ulcerative colitis (UC) and Crohn's disease (CD) patients undergoing colectomy during the cohort's prospective follow-up.

resultsOne hundred and twenty-one IBD patients (33 CD, 81 UC and seven unclassified) underwent colectomy during prospective follow-up in the Swiss Inflammatory Bowel Disease Cohort Study. Within the 114 patients with UC or CD any EIM was reported in 40 (nine CD and 31 UC) patients. Activity of EIMs ceased entirely after colectomy in 21 patients (52.5%). Complete cessation of EIM after colectomy was higher in patients with UC versus CD with 58.1% versus 33.3%. After colectomy, 29 out of the 114 patients (25.4%) experienced any EIM. Two thirds of these (19 patients) represented persisting EIMs, while in one third (10 patients) EIM represented a de-novo event after colectomy. Overall, 13.5% of IBD patients developed a de-novo EIM after colectomy.

conclusionsIn IBD patients undergoing colectomy, EIMs present prior to surgery will persist in about half of patients. Complete cessation of EIM after colectomy may be less common in CD than in UC. In patients who never experienced EIMs prior to colectomy de-novo manifestations thereafter should be expected in up to one in seven patients.

Indexed as

ColectomySymptom AssessmentAdolescentAdultAgedAged, 80 and overChildCohort StudiesColitis, UlcerativeCrohn DiseaseFemaleHumansKaplan-Meier EstimateMaleMiddle AgedProspective Studiescolectomyextraintestinal manifestationsinflammatory bowel disease

Identifiers

PMID34431613
PMCPMC8435245
OpenAlexW3194543742

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.