Evidence map›Paper›PMID 34431569›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2021

Amphiphilic Copolymers for Versatile, Facile, and In Situ Tunable Surface Biofunctionalization.

André Ruland, Saskia Schenker, Lucas Schirmer, Jens Friedrichs, Andrea Meinhardt, Véronique B Schwartz, Nadine Kaiser, Rupert Konradi, William MacDonald, Tina Helmecke and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Inflammation-Controlled Anti-Inflammatory Hydrogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

André RulandLeibniz Institute of Polymer Research Dresden (IPF), Max Bergmann Center of Biomaterials Dresden (MBC), Hohe Str. 6, 01069, Dresden, Germany.
Saskia SchenkerLeibniz Institute of Polymer Research Dresden (IPF), Max Bergmann Center of Biomaterials Dresden (MBC), Hohe Str. 6, 01069, Dresden, Germany.
Lucas SchirmerLeibniz Institute of Polymer Research Dresden (IPF), Max Bergmann Center of Biomaterials Dresden (MBC), Hohe Str. 6, 01069, Dresden, Germany.
Jens FriedrichsLeibniz Institute of Polymer Research Dresden (IPF), Max Bergmann Center of Biomaterials Dresden (MBC), Hohe Str. 6, 01069, Dresden, Germany.
Andrea MeinhardtLeibniz Institute of Polymer Research Dresden (IPF), Max Bergmann Center of Biomaterials Dresden (MBC), Hohe Str. 6, 01069, Dresden, Germany.
Véronique B SchwartzfaCellitate - A venture of Chemovator GmbH, Industriestr. 35, 68169, Mannheim, Germany.
Nadine KaiserBASF SE, RAM/OB - B001, Carl-Bosch-Strasse 38, 67056, Ludwigshafen am Rhein, Germany.
Rupert KonradiBASF SE, RAM/OB - B001, Carl-Bosch-Strasse 38, 67056, Ludwigshafen am Rhein, Germany.
William MacDonaldLeibniz Institute of Polymer Research Dresden (IPF), Max Bergmann Center of Biomaterials Dresden (MBC), Hohe Str. 6, 01069, Dresden, Germany.
Tina HelmeckeLeibniz Institute of Polymer Research Dresden (IPF), Max Bergmann Center of Biomaterials Dresden (MBC), Hohe Str. 6, 01069, Dresden, Germany.
Melissa K L N SikosanaLeibniz Institute of Polymer Research Dresden (IPF), Max Bergmann Center of Biomaterials Dresden (MBC), Hohe Str. 6, 01069, Dresden, Germany.
Juliane ValtinLeibniz Institute of Polymer Research Dresden (IPF), Max Bergmann Center of Biomaterials Dresden (MBC), Hohe Str. 6, 01069, Dresden, Germany.
Dominik HahnLeibniz Institute of Polymer Research Dresden (IPF), Max Bergmann Center of Biomaterials Dresden (MBC), Hohe Str. 6, 01069, Dresden, Germany.
Lars D RennerLeibniz Institute of Polymer Research Dresden (IPF), Max Bergmann Center of Biomaterials Dresden (MBC), Hohe Str. 6, 01069, Dresden, Germany.ORCID https://orcid.org/0000-0003-0178-1788
Carsten WernerLeibniz Institute of Polymer Research Dresden (IPF), Max Bergmann Center of Biomaterials Dresden (MBC), Hohe Str. 6, 01069, Dresden, Germany.ORCID https://orcid.org/0000-0003-0189-3448
Uwe FreudenbergLeibniz Institute of Polymer Research Dresden (IPF), Max Bergmann Center of Biomaterials Dresden (MBC), Hohe Str. 6, 01069, Dresden, Germany.ORCID https://orcid.org/0000-0002-1359-1095
Leibniz Institute of Polymer Research · DERobert Bosch (Germany) · DEBrown University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precision surface engineering is key to advanced biomaterials. A new platform of PEGylated styrene-maleic acid copolymers for adsorptive surface biofunctionalization is reported. Balanced amphiphilicity renders the copolymers water-soluble but strongly affine for surfaces. Fine-tuning of their molecular architecture provides control over adsorptive anchorage onto specific materials-which is why they are referred to as "anchor polymers" (APs)-and over structural characteristics of the adsorbed layers. Conjugatable with an array of bioactives-including cytokine-complexing glycosaminoglycans, cell-adhesion-mediating peptides and antimicrobials-APs can be applied to customize materials for demanding biotechnologies in uniquely versatile, simple, and robust ways. Moreover, homo- and heterodisplacement of adsorbed APs provide unprecedented means of in situ alteration and renewal of the functionalized surfaces. The related options are exemplified with proof-of-concept experiments of controlled bacterial adhesion, human umbilical vein endothelial cell, and induced pluripotent cell growth on AP-functionalized surfaces.

Indexed as

Anti-Infective AgentsBiocompatible MaterialsCell AdhesionCytokinesGlycosaminoglycansGram-Negative BacteriaGram-Positive BacteriaHumansHuman Umbilical Vein Endothelial CellsInduced Pluripotent Stem CellsMaleatesOligopeptidesPolyethylene GlycolsPolymersStyreneSurface PropertiesAnti-Infective Agentsarginyl-glycyl-aspartic acidBiocompatible MaterialsCytokinesGlycosaminoglycansMaleatesmaleic acidOligopeptidesPolyethylene GlycolsPolymersStyreneadsorptive surface functionalizationantimicrobial surface propertiescell-instructive propertiesstyrene-maleic anhydride copolymers

Identifiers

PMID34431569
PMCPMC11468472
OpenAlexW3195391997

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.