Evidence map›Paper›PMID 34431415›Full record

ReviewPhysiology (Bethesda, Md.)2021

Halogen-Induced Chemical Injury to the Mammalian Cardiopulmonary Systems.

Dylan R Addis, Saurabh Aggarwal, Ahmed Lazrak, Tamas Jilling, Sadis Matalon

Open access · greenAbstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. The long road to Ithaca: a physiologist's journey.American journal of physiology. Cell physiology · 2025
    Review
  4. Article
  5. Myocardial SERCA2 Protects Against Cardiac Damage and Dysfunction Caused by Inhaled Bromine.The Journal of pharmacology and experimental therapeutics · 2024
    Article
  6. Hemopexin reverses activation of lung eIF2α and decreases mitochondrial injury in chlorine-exposed mice.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  7. Countermeasures against Pulmonary Threat Agents.The Journal of pharmacology and experimental therapeutics · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Low molecular weight hyaluronan inhibits lung epithelial ion channels by activating the calcium-sensing receptor.Matrix biology : journal of the International Society for Matrix Biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dylan R AddisDepartment of Anesthesiology and Perioperative Medicine, Division of Cardiothoracic Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama.
Saurabh AggarwalDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, University of Alabama at Birmingham, Birmingham, Alabama.
Ahmed LazrakDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, University of Alabama at Birmingham, Birmingham, Alabama.
Tamas JillingPulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Sadis MatalonDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, University of Alabama at Birmingham, Birmingham, Alabama.
University of Alabama at Birmingham · USComprehensive Cardiovascular · US

Funding

Bromine Inhalation Induced Lung Injury: Novel Mechanisms and Treatment StrategiesU01ES026458 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MATALON, SADIS · 2015 to 2019
$3.9M
CIALIS® reverses halogen induced injury to pregnant animals and their offspringU01ES027697 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JILLING, TAMAS SANDOR, MATALON, SADIS · 2016 to 2020
$3.7M
UAB Institutional Career Development Program in HIV-Related Heart, Lung, Blood and ResearchK12HL143958 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HEATH, SONYA L · 2018 to 2022
$1.6M
Basic and Translational Science in Heart FailureT32HL129948 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YOUNG, MARTIN E · 2017 to 2021
$1.4M
Esomeprazole counteracts chlorine toxicity in pregnant animalsR21ES031559 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JILLING, TAMAS SANDOR · 2021 to 2022
$408k
NHLBI NIH HHS K12 HL143958NHLBI NIH HHS T32 HL129948NIEHS NIH HHS R21 ES031559NIEHS NIH HHS U01 ES026458NIEHS NIH HHS U01 ES027697
6 · The paper itself

Abstract

The halogens chlorine (Cl

Indexed as

BromineHalogensAnimalsChlorineHumansLungBromineChlorineHalogensantioxidantsARDSbrominechlorineheme

Identifiers

PMID34431415
PMCPMC8807065
OpenAlexW3194599578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.