Evidence map›Paper›PMID 34431407›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2021

Circadian clock core component Bmal1 dictates cell cycle rhythm of proliferating hepatocytes during liver regeneration.

Huaizhou Jiang, Veronica Garcia, Jennifer Abla Yanum, Joonyong Lee, Guoli Dai

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. PPAR-PPAR research · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Huaizhou JiangSchool of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei, China.
Veronica GarciaDepartment of Biology, School of Science, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana.
Jennifer Abla YanumDepartment of Biology, School of Science, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana.
Joonyong LeeDepartment of Biology, School of Science, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana.
Guoli DaiDepartment of Biology, School of Science, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana.ORCID 0000-0002-3588-4796
University of Indianapolis · US

Funding

Molecular Regulation of Hepatocyte Proliferation and Liver RegenerationR01DK117076 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DAI, GUOLI · 2019 to 2022
$1.4M
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 1R01DK117076NIDDK NIH HHS R01 DK117076
6 · The paper itself

Abstract

After partial hepatectomy (PH), the majority of remnant hepatocytes synchronously enter and rhythmically progress through the cell cycle for three major rounds to regain lost liver mass. Whether and how the circadian clock core component Bmal1 modulates this process remains elusive. We performed PH on

Indexed as

Cell CycleCell ProliferationCircadian RhythmLiver RegenerationAnimalsARNTL Transcription FactorsErbB ReceptorsHepatocytesMiceMice, Inbred C57BLMitosisNF-E2-Related Factor 2Proto-Oncogene Proteins c-metSignal TransductionARNTL Transcription FactorsBmal1 protein, mouseErbB ReceptorsNfe2l2 protein, mouseNF-E2-Related Factor 2Proto-Oncogene Proteins c-metBmal1cell cyclefat accumulationhepatocyte proliferationliver regeneration

Identifiers

PMID34431407
PMCPMC8560370
OpenAlexW3195518365

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.