Evidence map›Paper›PMID 34431359›Full record

ArticleJournal of the American Heart Association2021

Trends in Prepregnancy Obesity and Association With Adverse Pregnancy Outcomes in the United States, 2013 to 2018.

Michael C Wang, Priya M Freaney, Amanda M Perak, Philip Greenland, Donald M Lloyd-Jones, William A Grobman, Sadiya S Khan

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06932250 (Vascular and Neural Mechanisms of Chronic Leg Heating in Pregnant Women With Obesity), which is not on this map. Cited by 73 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 3 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06932250 narecruitingnot on this mapstarted 2025, after this paper: background citation

Vascular and Neural Mechanisms of Chronic Leg Heating in Pregnant Women With Obesity

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2025 to 2030Enrolled118ConditionsHigh-risk PregnancyArmsLeg heating
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 3 syntheses or guidelines pooled it, 113 citations in OpenAlex.

  1. Guideline
  2. Association between maternal adiposity measures and adverse maternal outcomes of pregnancy: Systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
    Pooled it
  3. Optimal blood pressure target to prevent severe hypertension in pregnancy: A systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Pooled it
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Prepregnancy body mass index in Ontario from 2012 to 2022: A population-based descriptive study.Canadian journal of public health = Revue canadienne de sante publique · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Observational
  20. Longitudinal changes in cardiovascular and sympathetic neural responses to static handgrip exercise throughout pregnancy.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Michael C WangDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL.ORCID 0000-0002-1042-8428
Priya M FreaneyDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL.ORCID 0000-0001-6466-2407
Amanda M PerakDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL.ORCID 0000-0003-1025-0997
Philip GreenlandDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL.ORCID 0000-0002-6327-2439
Donald M Lloyd-JonesDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL.ORCID 0000-0003-0847-6110
William A GrobmanDepartment of Obstetrics and Gynecology Northwestern University Feinberg School of Medicine Chicago IL.
Sadiya S KhanDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL.ORCID 0000-0003-0643-1859
Northwestern University · US

Funding

The Claude D. Pepper Older Americans Independence Center (OAIC) at Northwestern UniversityP30AG059988 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MCDERMOTT, MARY MCGRAE · 2020 to 2024
$7.1M
A self-regulation approach to diabetes adherence into emerging adulthoodR01DK092939 · NIDDK · UNIVERSITY OF UTAH · PI BERG, CYNTHIA A, WIEBE, DEBORAH J · 2011 to 2015
$2.7M
NIA NIH HHS P30 AG059988NIDDK NIH HHS R01 DK092939
6 · The paper itself

Abstract

Background The prevalence of obesity in the population has increased in parallel with increasing rates of adverse pregnancy outcomes (APOs). Quantifying contemporary trends in prepregnancy obesity and associations with interrelated APOs (preterm birth, low birth weight, and pregnancy-associated hypertension) together and individually can inform prevention strategies to optimize cardiometabolic health in women and offspring. Methods and Results We performed a serial, cross-sectional study using National Center for Health Statistics birth certificate data including women aged 15 to 44 years with live singleton births between 2013 and 2018, stratified by race/ethnicity (non-Hispanic White, non-Hispanic Black, Hispanic, and non-Hispanic Asian). We quantified the annual prevalence of prepregnancy obesity (body mass index ≥30.0 kg/m

Indexed as

HypertensionObesityPremature BirthCross-Sectional StudiesFemaleHispanic or LatinoHumansInfant, NewbornPregnancyPregnancy OutcomeUnited Statesadverse pregnancy outcomesobesitypopulation attributable fractionprimordial preventionracial disparities

Identifiers

PMID34431359
PMCPMC8649260
OpenAlexW3195462718

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.