Evidence map›Paper›PMID 34431125›Full record

ArticleHistopathology2021

Epstein-Barr virus reactivation influences clonal evolution in human herpesvirus-8-related lymphoproliferative disorders.

Massimo Granai, Mattia Facchetti, Virginia Mancini, Jacqueline Goedhals, Alicia Sherriff, Lucia Mundo, Cristiana Bellan, Teresa Amato, Ester Sorrentino, Marco Ungari and 4 more

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Histopathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 5 countries.

Massimo GranaiSection of Pathology, Department of Medical Biotechnology, University of Siena, Siena, Italy.
Mattia FacchettiSection of Pathology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0003-2605-101X
Virginia ManciniSection of Pathology, Department of Medical Biotechnology, University of Siena, Siena, Italy.ORCID https://orcid.org/0000-0002-4775-3777
Jacqueline GoedhalsDepartment of Pathology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
Alicia SherriffDepartment of Oncology, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
Lucia MundoHealth Research Institute, University of Limerick, Limerick, Ireland.
Cristiana BellanSection of Pathology, Department of Medical Biotechnology, University of Siena, Siena, Italy.
Teresa AmatoSection of Pathology, Department of Medical Biotechnology, University of Siena, Siena, Italy.
Ester SorrentinoSection of Pathology, Department of Medical Biotechnology, University of Siena, Siena, Italy.
Marco UngariDepartment of Pathology, Cremona Hospital, Cremona, Italy.
Martine RaphaelUniversity of Paris Sud, Paris, France.
Lorenzo LeonciniSection of Pathology, Department of Medical Biotechnology, University of Siena, Siena, Italy.ORCID https://orcid.org/0000-0002-7457-300X
Fabio FacchettiSection of Pathology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Stefano LazziSection of Pathology, Department of Medical Biotechnology, University of Siena, Siena, Italy.
University of Siena · ITUniversity of Brescia · ITUniversity of the Free State · ZAIstituti Ospitalieri di Cremona · ITUniversité Paris-Sud · FRUniversity of Limerick · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman herpesvirus-8 (HHV8) is a lymphotropic virus associated with different lymphoproliferative disorders, including primary effusion lymphoma (PEL), multicentric Castleman's disease (MCD), diffuse large B-cell lymphomas, not otherwise specified, and the rare entity known as germinotropic lymphoproliferative disorder (GLPD). In PELs and GLPD the neoplastic cells also contain Epstein-Barr virus (EBV). In addition, occasional cases with atypical and overlapping features among these entities have been recognised, suggesting that the spectrum of the HHV8-related lesions may not be fully characterised.

aimsHere, we report two cases of lymphoproliferative disorder associated with HHV8 and EBV that further expand the spectrum of HHV8/EBV-positive lymphoproliferative disease. METHODS AND

resultsCase 1 represented HHV8/EBV-positive extracavitary nodal PEL followed by pleural PEL. The striking characteristic of this case was the almost focal and intrasinusoidal localisation of the neoplastic cells and the association with Castleman's disease features. In the second case, we found the entire spectrum of HHV8-related disorders, i.e. MCD, GLPD, and PEL, coexisting in the same lymph node, underlining the variability, possible overlap and evolution among these entities. Both cases were well analysed with immunohistochemistry, determination of the EBV latency programme, and molecular analysis for clonality of immnoglobulin genes. In both patients, the disease followed an unexpected indolent course, both being still alive after 8 and 12 months, respectively.

conclusionOur findings represent further evidence of the overlap among HHV8/EBV-positive lymphoproliferative disorders, and underline a grey zone that requires further study; they further confirm the experimental evidence that lytic EBV replication influences HHV8-related tumorigenesis.

Indexed as

Virus ActivationAgedClonal EvolutionCoinfectionEpstein-Barr Virus InfectionsFemaleHerpesviridae InfectionsHerpesvirus 4, HumanHerpesvirus 8, HumanHumansLymphoproliferative DisordersMaleMiddle AgedCastleman’s diseaseEBVgerminotropic lymphoproliferative disorderKSHV/HHV8lymphomapleural effusion

Identifiers

PMID34431125
PMCPMC9293042
OpenAlexW3193911230

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.